Psykologisk Institut

Genome-wide association study of response to cognitive-behavioural therapy in children with anxiety disorders

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Jonathan R I Coleman
  • ,
  • Kathryn J Lester
  • ,
  • Robert Keers
  • ,
  • Susanna Roberts
  • ,
  • Charles Curtis
  • ,
  • Kristian Arendt
  • ,
  • Susan Bögels
  • ,
  • Peter Cooper
  • ,
  • Cathy Creswell
  • ,
  • Tim Dalgleish
  • ,
  • Catharina A Hartman
  • ,
  • Einar R Heiervang
  • ,
  • Katrin Hötzel
  • ,
  • Jennifer L Hudson
  • ,
  • Tina In-Albon
  • ,
  • Kristen Lavallee
  • ,
  • Heidi J Lyneham
  • ,
  • Carla E Marin
  • ,
  • Richard Meiser-Stedman
  • ,
  • Talia Morris
  • ,
  • Maaike H Nauta
  • ,
  • Ronald M Rapee
  • ,
  • Silvia Schneider
  • ,
  • Sophie C Schneider
  • ,
  • Wendy K Silverman
  • ,
  • Mikael Thastum
  • Kerstin Thirlwall
  • ,
  • Polly Waite
  • ,
  • Gro Janne Wergeland
  • ,
  • Gerome Breen
  • ,
  • Thalia C Eley

BACKGROUND: Anxiety disorders are common, and cognitive-behavioural therapy (CBT) is a first-line treatment. Candidate gene studies have suggested a genetic basis to treatment response, but findings have been inconsistent.

AIMS: To perform the first genome-wide association study (GWAS) of psychological treatment response in children with anxiety disorders (n = 980).

METHOD: Presence and severity of anxiety was assessed using semi-structured interview at baseline, on completion of treatment (post-treatment), and 3 to 12 months after treatment completion (follow-up). DNA was genotyped using the Illumina Human Core Exome-12v1.0 array. Linear mixed models were used to test associations between genetic variants and response (change in symptom severity) immediately post-treatment and at 6-month follow-up.

RESULTS: No variants passed a genome-wide significance threshold (P = 5×10(-8)) in either analysis. Four variants met criteria for suggestive significance (P<5×10(-6)) in association with response post-treatment, and three variants in the 6-month follow-up analysis.

CONCLUSIONS: This is the first genome-wide therapygenetic study. It suggests no common variants of very high effect underlie response to CBT. Future investigations should maximise power to detect single-variant and polygenic effects by using larger, more homogeneous cohorts.

OriginalsprogEngelsk
TidsskriftBritish Journal of Psychiatry
Vol/bind209
Nummer3
Sider (fra-til)236-243
Antal sider8
ISSN0007-1250
DOI
StatusUdgivet - sep. 2016

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