TY - JOUR
T1 - Genome-wide association study reveals a locus in ADARB2 for complete freedom from headache in Danish Blood Donors
AU - Olofsson, Isa Amalie
AU - Kristjansson, Ragnar P.
AU - Callesen, Ida
AU - Davidsson, Olafur
AU - Winsvold, Bendik
AU - Hjalgrim, Henrik
AU - Ostrowski, Sisse R.
AU - Erikstrup, Christian
AU - Bruun, Mie Topholm
AU - Pedersen, Ole Birger
AU - Burgdorf, Kristoffer S.
AU - Banasik, Karina
AU - Sørensen, Erik
AU - Mikkelsen, Christina
AU - Didriksen, Maria
AU - Dinh, Khoa Manh
AU - Mikkelsen, Susan
AU - Brunak, Søren
AU - Ullum, Henrik
AU - Chalmer, Mona Ameri
AU - Olesen, Jes
AU - Kogelman, Lisette J.A.
AU - Hansen, Thomas Folkmann
AU - International Headache Genetic Consortium
AU - DBDS Genomic Consortium
N1 - Publisher Copyright:
© 2024. The Author(s).
PY - 2024/5/27
Y1 - 2024/5/27
N2 - Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from headache, we performed a genome-wide association study of individuals who have never experienced a headache. We included 63,992 individuals (2,998 individuals with complete freedom from headache and 60,994 controls) from the Danish Blood Donor Study Genomic Cohort. Participants were included in two rounds, from 2015 to 2018 and in 2020. We discovered a genome-wide significant association, with the lead variant rs7904615[G] in ADARB2 (EAF = 27%, OR = 1.20 [1.13-1.27], p = 3.92 × 10-9). The genomic locus was replicated in a non-overlapping cohort of 13,032 individuals (539 individuals with complete freedom from headache and 12,493 controls) from the Danish Blood Donor Study Genomic Cohort (p < 0.05, two-sided). Participants for the replication were included from 2015 to 2020. In conclusion, we show that complete freedom from headache has a genetic component, and we suggest that ADARB2 is involved in complete freedom from headache. The genomic locus was specific for complete freedom from headache and was not associated with any primary headache disorders.
AB - Headache disorders are the most common disorders of the nervous system. The lifetime prevalence of headache disorders show that some individuals never experience headache. The etiology of complete freedom from headache is not known. To assess genetic variants associated with complete freedom from headache, we performed a genome-wide association study of individuals who have never experienced a headache. We included 63,992 individuals (2,998 individuals with complete freedom from headache and 60,994 controls) from the Danish Blood Donor Study Genomic Cohort. Participants were included in two rounds, from 2015 to 2018 and in 2020. We discovered a genome-wide significant association, with the lead variant rs7904615[G] in ADARB2 (EAF = 27%, OR = 1.20 [1.13-1.27], p = 3.92 × 10-9). The genomic locus was replicated in a non-overlapping cohort of 13,032 individuals (539 individuals with complete freedom from headache and 12,493 controls) from the Danish Blood Donor Study Genomic Cohort (p < 0.05, two-sided). Participants for the replication were included from 2015 to 2020. In conclusion, we show that complete freedom from headache has a genetic component, and we suggest that ADARB2 is involved in complete freedom from headache. The genomic locus was specific for complete freedom from headache and was not associated with any primary headache disorders.
UR - http://www.scopus.com/inward/record.url?scp=85194521800&partnerID=8YFLogxK
U2 - 10.1038/s42003-024-06299-y
DO - 10.1038/s42003-024-06299-y
M3 - Journal article
C2 - 38802570
AN - SCOPUS:85194521800
SN - 2399-3642
VL - 7
SP - 646
JO - Communications Biology
JF - Communications Biology
IS - 1
M1 - 646
ER -