Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation

Wossenie Mebratie*, Henry Reyer, Klaus Wimmers, Henk Bovenhuis, Just Jensen

*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

33 Citationer (Scopus)
126 Downloads (Pure)

Abstract

Genome wide association study was conducted using a mixed linear model (MLM) approach that accounted for family structure to identify single nucleotide polymorphisms (SNPs) and candidate genes associated with body weight (BW) and feed efficiency (FE) traits in a broiler chicken population. The results of the MLM approach were compared with the results of a general linear model approach that does not take family structure in to account. In total, 11 quantitative trait loci (QTL) and 21 SNPs, were identified to be significantly associated with BW traits and 5 QTL and 5 SNPs were found associated with FE traits using MLM approach. Besides some overlaps between the results of the two GWAS approaches, there are considerable differences in the detected QTL. Even though the genomic inflation factor (λ) values indicate that there is no strong family structure in this population, using models that account for the existing family structure may reduce bias and increase accuracy of the estimated SNP effects in the association analysis. The SNPs and candidate genes identified in this study provide information on the genetic background of BW and FE traits in broiler chickens and might be used as prior information for genomic selection.

OriginalsprogEngelsk
Artikelnummer922
TidsskriftScientific Reports
Vol/bind9
Antal sider10
ISSN2045-2322
DOI
StatusUdgivet - 1 dec. 2019

Fingeraftryk

Dyk ned i forskningsemnerne om 'Genome wide association study of body weight and feed efficiency traits in a commercial broiler chicken population, a re-visitation'. Sammen danner de et unikt fingeraftryk.

Citationsformater