Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle

TY - JOUR

T1 - Genome-wide association study identifies loci linked to serum electrolyte traits in Chinese Holstein cattle

AU - Gan, Q. F.

AU - Li, Y. R.

AU - Lund, M.

AU - Su, G. S.

AU - Liang, X. W.

PY - 2019/12

Y1 - 2019/12

N2 - We aimed to identify QTL for serum electrolyte traits by performing a GWAS of calcium, chloride, sodium, potassium and magnesium ion concentrations in Chinese Holstein cattle. We detected five SNPs that had significant associations with calcium ion concentrations and identified GATA2 from Bos taurus chromosome (BTA)22 as having the highest significance. Among the genes with significant results, we speculate that TMEM123 might be related to calcium channel proteins according to the functions of the TMEM family.

AB - We aimed to identify QTL for serum electrolyte traits by performing a GWAS of calcium, chloride, sodium, potassium and magnesium ion concentrations in Chinese Holstein cattle. We detected five SNPs that had significant associations with calcium ion concentrations and identified GATA2 from Bos taurus chromosome (BTA)22 as having the highest significance. Among the genes with significant results, we speculate that TMEM123 might be related to calcium channel proteins according to the functions of the TMEM family.

KW - Calcium ions

KW - Chloride ion

KW - Dairy cattle

KW - FarmCPU

KW - GATA2

UR - http://www.scopus.com/inward/record.url?scp=85073930581&partnerID=8YFLogxK

U2 - 10.1111/age.12851

DO - 10.1111/age.12851

M3 - Journal article

C2 - 31531898

AN - SCOPUS:85073930581

SN - 0268-9146

VL - 50

SP - 744

EP - 748

JO - Animal Genetics

JF - Animal Genetics

IS - 6

ER -