Aarhus Universitets segl

Genetics of eating disorders in the genome-wide era

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

  • Hunna J. Watson, University of North Carolina, University of Western Australia, Curtin University
  • ,
  • Alish B. Palmos, King's College London
  • ,
  • Avina Hunjan, King's College London, South London and Maudsley NHS Foundation Trust
  • ,
  • Jessica H. Baker, University of North Carolina
  • ,
  • Zeynep Yilmaz
  • Helena L. Davies, King's College London

Enabled by advances in high throughput genomic sequencing and an unprecedented level of global data sharing, molecular genetic research is beginning to unlock the biological basis of eating disorders. This invited review provides an overview of genetic discoveries in eating disorders in the genome-wide era. To date, five genome-wide association studies on eating disorders have been conducted- A ll on anorexia nervosa (AN). For AN, several risk loci have been detected, and ~11-17% of the heritability has been accounted for by common genetic variants. There is extensive genetic overlap between AN and psychological traits, especially obsessive-compulsive disorder, and intriguingly, with metabolic phenotypes even after adjusting for body mass index (BMI) risk variants. Furthermore, genetic risk variants predisposing to lower BMI may be causal risk factors for AN. Causal genes and biological pathways of eating disorders have yet to be elucidated and will require greater sample sizes and statistical power, and functional follow-up studies. Several studies are underway to recruit individuals with bulimia nervosa and binge-eating disorder to enable further genome-wide studies. Data collections and research labs focused on the genetics of eating disorders have joined together in a global effort with the Psychiatric Genomics Consortium. Molecular genetics research in the genome-wide era is improving knowledge about the biology behind the established heritability of eating disorders. This has the potential to offer new hope for understanding eating disorder etiology and for overcoming the therapeutic challenges that confront the eating disorder field.

OriginalsprogEngelsk
TidsskriftPsychological Medicine
Vol/bind51
Nummer13
Sider (fra-til)2287-2297
Antal sider11
ISSN0033-2917
DOI
StatusUdgivet - okt. 2021

Bibliografisk note

Publisher Copyright:
Copyright © The Author(s), 2021. Published by Cambridge University Press.

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