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Genetic architecture of ADHD and overlap with other psychiatric disorders and cognition-related phenotypes
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review
DOI
- https://doi.org/10.1016/j.neubiorev.2023.105313
Forlagets udgivne version
- M. Ribasés, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, Carlos III Health Institute (ISCIII), University of Barcelona ,
- M. Mitjans, Carlos III Health Institute (ISCIII), University of Barcelona, Institut de Recerca Sant Joan de Déu (IR-SJD) ,
- C. A. Hartman, University of Groningen ,
- M. Soler Artigas, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, Carlos III Health Institute (ISCIII), University of Barcelona ,
- D. Demontis
- H. Larsson, Örebro Universitet, Karolinska Institutet ,
- J. A. Ramos-Quiroga, Hospital Universitari Vall d'Hebron, Autonomous University of Barcelona, Carlos III Health Institute (ISCIII) ,
- J. Kuntsi, King's College London ,
- S. V. Faraone, SUNY Upstate Medical University ,
- A. D. Børglum
- A. Reif, Goethe University Frankfurt ,
- B. Franke, Radboud University Nijmegen ,
- B. Cormand, University of Barcelona, Institut de Recerca Sant Joan de Déu (IR-SJD), Carlos III Health Institute (ISCIII)
Attention-deficit/hyperactivity disorder (ADHD) co-occurs with many other psychiatric disorders and traits. In this review, we summarize and interpret the existing literature on the genetic architecture of these comorbidities based on hypothesis-generating approaches. Quantitative genetic studies indicate that genetic factors play a substantial role in the observed co-occurrence of ADHD with many different disorders and traits. Molecular genetic correlations derived from genome-wide association studies and results of studies based on polygenic risk scores confirm the general pattern but provide effect estimates that are smaller than those from twin studies. The identification of the specific genetic variants and biological pathways underlying co-occurrence using genome-wide approaches is still in its infancy. The first analyses of causal inference using genetic data support causal relationships between ADHD and comorbid disorders, although bidirectional effects identified in some instances point to complex relationships. While several issues in the methodology and inferences from the results are still to be overcome, this review shows that the co-occurrence of ADHD with many psychiatric disorders and traits is genetically interpretable.
| Originalsprog | Engelsk |
|---|---|
| Artikelnummer | 105313 |
| Tidsskrift | Neuroscience and Biobehavioral Reviews |
| Vol/bind | 153 |
| Antal sider | 20 |
| ISSN | 0149-7634 |
| DOI | |
| Status | Udgivet - okt. 2023 |
Se relationer på Aarhus Universitet Citationsformater
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