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Genetic and environmental influence on DNA strand break repair: a twin study

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  • Christian Garm
  • Maria Moreno-Villanueva
  • ,
  • Alexander Bürkle
  • ,
  • Lisbeth Aagaard Larsen, Epidemiologi, Biostatistik og Biodemografi, Danmark
  • Vilhelm A Bohr, Laboratory of Molecular Gerontology, National Institute on Aging, National Institutes of Health, USA
  • Kaare Christensen, Syddansk Universitet, Danmark
  • Tinna V. Stevnsner
Accumulation of DNA damage deriving from exogenous and endogenous sources has significant consequences for cellular survival, and is implicated in aging, cancer, and neurological diseases. Different DNA repair pathways have evolved in order to maintain genomic stability. Genetic and environmental factors are likely to influence DNA repair capacity. In order to gain more insight into the genetic and environmental contribution to the molecular basis of DNA repair, we have performed a human twin study, where we focused on the consequences of some of the most abundant types of DNA damage (single-strand breaks), and some of the most hazardous lesions (DNA double-strand breaks). DNA damage signaling response (Gamma-H2AX signaling), relative amount of endogenous damage, and DNA-strand break repair capacities were studied in peripheral blood mononuclear cells from 198 twins (94 monozygotic and 104 dizygotic). We did not detect genetic effects on the DNA-strand break variables in our study.
OriginalsprogEngelsk
TidsskriftEnvironmental and Molecular Mutagenesis
Vol/bind54
Nummer6
Sider (fra-til)414-420
Antal sider6
ISSN0893-6692
DOI
StatusUdgivet - jul. 2013

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