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Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality. / Adewuyi, Emmanuel O; Mehta, Divya; Sapkota, Yadav et al.
I: Human Genetics, Bind 140, Nr. 3, 03.2021, s. 529-552.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
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TY - JOUR
T1 - Genetic analysis of endometriosis and depression identifies shared loci and implicates causal links with gastric mucosa abnormality
AU - Adewuyi, Emmanuel O
AU - Mehta, Divya
AU - Sapkota, Yadav
AU - International Endogene Consortium (IEC)
AU - 23andMe Research Team
AU - Auta, Asa
AU - Yoshihara, Kosuke
AU - Nyegaard, Mette
AU - Griffiths, Lyn R
AU - Montgomery, Grant W
AU - Chasman, Daniel I
AU - Nyholt, Dale R
PY - 2021/3
Y1 - 2021/3
N2 - Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (PFsig-permuted = 9.99 x 10(-4)). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (r(G) = 0.27,P = 8.85 x 10(-27)). A meta-analysis of endometriosis and depression GWAS (sample size = 709,111), identified 20 independent genome-wide significant loci (P <5 x 10(-8)), of which eight are novel. Mendelian randomization analysis (MR) suggests a causal effect of depression on endometriosis. Combining gene-based association results across endometriosis and depression GWAS, we identified 22 genes with a genome-wide significant Fisher's combinedPvalue (FCPgene <2.75 x 10(-6)). Genes with a nominal gene-based association (P-gene <0.05) were significantly enriched across endometriosis and depression (Pbinomial-test = 2.90 x 10(-4)). Also, genes overlapping the two traits atP(gene) <0.1 (Pbinomial-test = 1.31 x 10(-5)) were significantly enriched for the biological pathways 'cell-cell adhesion', 'inositol phosphate metabolism', 'Hippo-Merlin signaling dysregulation' and 'gastric mucosa abnormality'. These results reveal a shared genetic etiology for endometriosis and depression. Indeed, additional analyses found evidence of a causal association between each of endometriosis and depression and at least one abnormal condition of gastric mucosa. Our study confirms the comorbidity of endometriosis and depression, implicates links with gastric mucosa abnormalities in their causal pathways and reveals potential therapeutic targets for further investigation.
AB - Evidence from observational studies indicates that endometriosis and depression often co-occur. However, conflicting evidence exists, and the etiology as well as biological mechanisms underlying their comorbidity remain unknown. Utilizing genome-wide association study (GWAS) data, we comprehensively assessed the relationship between endometriosis and depression. Single nucleotide polymorphism effect concordance analysis (SECA) found a significant genetic overlap between endometriosis and depression (PFsig-permuted = 9.99 x 10(-4)). Linkage disequilibrium score regression (LDSC) analysis estimated a positive and highly significant genetic correlation between the two traits (r(G) = 0.27,P = 8.85 x 10(-27)). A meta-analysis of endometriosis and depression GWAS (sample size = 709,111), identified 20 independent genome-wide significant loci (P <5 x 10(-8)), of which eight are novel. Mendelian randomization analysis (MR) suggests a causal effect of depression on endometriosis. Combining gene-based association results across endometriosis and depression GWAS, we identified 22 genes with a genome-wide significant Fisher's combinedPvalue (FCPgene <2.75 x 10(-6)). Genes with a nominal gene-based association (P-gene <0.05) were significantly enriched across endometriosis and depression (Pbinomial-test = 2.90 x 10(-4)). Also, genes overlapping the two traits atP(gene) <0.1 (Pbinomial-test = 1.31 x 10(-5)) were significantly enriched for the biological pathways 'cell-cell adhesion', 'inositol phosphate metabolism', 'Hippo-Merlin signaling dysregulation' and 'gastric mucosa abnormality'. These results reveal a shared genetic etiology for endometriosis and depression. Indeed, additional analyses found evidence of a causal association between each of endometriosis and depression and at least one abnormal condition of gastric mucosa. Our study confirms the comorbidity of endometriosis and depression, implicates links with gastric mucosa abnormalities in their causal pathways and reveals potential therapeutic targets for further investigation.
KW - FACTORS CONTRIBUTE
KW - GASTROESOPHAGEAL-REFLUX DISEASE
KW - GENOME-WIDE ASSOCIATION
KW - MAJOR DEPRESSION
KW - MENDELIAN RANDOMIZATION
KW - PELVIC PAIN
KW - PROTON-PUMP INHIBITORS
KW - QUALITY-OF-LIFE
KW - WEB SERVER
KW - WOMEN
U2 - 10.1007/s00439-020-02223-6
DO - 10.1007/s00439-020-02223-6
M3 - Journal article
C2 - 32959083
VL - 140
SP - 529
EP - 552
JO - Human Genetics
JF - Human Genetics
SN - 0340-6717
IS - 3
ER -