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Generic Structures of Cytotoxic Liprotides: Nano-Sized Complexes with Oleic Acid Cores and Shells of Disordered Proteins

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

DOI

  • Jørn D Kaspersen, Danmark
  • Jannik N Pedersen, Danmark
  • Jon G Hansted, Danmark
  • Søren B Nielsen, Danmark
  • Srinivasan Sakthivel, Aarhus Universitet, Danmark
  • Kristina Wilhelm, Umeå University, Sverige
  • Ekaterina L Nemashkalova, Institute for Biological Instrumentation of the Russian Academy of Sciences and Pushchino State Institute of Natural Sciences, Rusland
  • Sergei E Permyakov, Institute for Biological Instrumentation of the Russian Academy of Sciences and Pushchino State Institute of Natural Sciences, Rusland
  • Eugene A Permyakov, Institute for Biological Instrumentation of the Russian Academy of Sciences and Pushchino State Institute of Natural Sciences, Rusland
  • Cristiano Luis Pinto Oliveira, Department of Experimental Physics, University of Sao Paulo, 66318, São Paulo 05314-970 (Brazil), Brasilien
  • Ludmilla A Morozova-Roche, Umeå University, Sverige
  • Daniel Otzen
  • Jan Skov Pedersen
The cytotoxic complex formed between α-lactalbumin and oleic acid (OA) has inspired many studies on protein-fatty acid complexes, but structural insight remains sparse. After having used small-angle X-ray scattering (SAXS) to obtain structural information, we present a new, generic structural model of cytotoxic protein-oleic acid complexes, which we have termed liprotides (lipids and partially denatured proteins). Twelve liprotides formed from seven structurally unrelated proteins and prepared by different procedures all displayed core-shell structures, each with a micellar OA core and a shell consisting of flexible, partially unfolded protein, which stabilizes the OA micelle. The common structure explains similar effects exerted on cells by different liprotides and is consistent with a cargo off-loading of the OA into cell membranes.
OriginalsprogEngelsk
TidsskriftChemBioChem
Vol/bind10
Nummer18
Sider (fra-til)2693-2702
Antal sider10
ISSN1439-4227
DOI
StatusUdgivet - dec. 2014

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