GeneRecon—A coalescent based tool for fine-scale association mapping

Thomas Mailund, Mikkel Heide Schierup, Christian Nørgaard Storm Pedersen, Jesper Nymann Madsen, Jotun Hein, Leif Schauser

    Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

    Abstract

    GeneRecon is a tool for fine-scale association mapping using a coalescence model. GeneRecon takes as input case-control data from phased or unphased SNP and micro-satellite genotypes. The posterior distribution of disease locus position is obtained by Metropolis Hastings sampling in the state space of genealogies. Input format, search strategy, and the sampled statistics can be configured through the Guile Scheme programming language embedded in GeneRecon, making GeneRecon highly configurable.
    OriginalsprogEngelsk
    TidsskriftBioinformatics
    Vol/bind22
    Nummer18
    Sider (fra-til)2317–2318
    Antal sider2
    ISSN1367-4803
    StatusUdgivet - 2006

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