Gallstones and incident colorectal cancer in a large pan-European cohort study

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  • Heather A Ward, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Neil Murphy, International Agency for Research on Cancer Lyon, France., Frankrig
  • Elisabete Weiderpass, Genetic Epidemiology Group, Folkhälsan Research Centre and Faculty of Medicine, University of Helsinki, Helsinki, Finland., Finland
  • Michael F Leitzmann, Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany., Tyskland
  • Elom Aglago, International Agency for Research on Cancer Lyon, France., Frankrig
  • Marc J Gunter, International Agency for Research on Cancer Lyon, France., Frankrig
  • Heinz Freisling, International Agency for Research on Cancer Lyon, France., Frankrig
  • Mazda Jenab, International Agency for Research on Cancer Lyon, France., Frankrig
  • Marie-Christine Boutron-Ruault, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Gianluca Severi, Institut Gustave Roussy, Villejuif, France., Frankrig
  • Franck Carbonnel, Department of Gastroenterology, Bicêtre University Hospital, Public Assistance Hospitals of Paris, Le Kremlin Bicêtre, France., Frankrig
  • Tilman Kühn, Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Foundation under Public Law, Heidelberg, Germany., Tyskland
  • Rudolf Kaaks, Division of Cancer Epidemiology, German Cancer Research Centre (DKFZ), Foundation under Public Law, Heidelberg, Germany., Tyskland
  • Heiner Boeing, Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke (DIfE), Nuthetal, 14558, Germany., Tyskland
  • Anne Tjønneland, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Anja Olsen
  • Kim Overvad
  • Susana Merino, Public Health Directorate, Asturias, Spain., Spanien
  • Raul Zamora-Ros, Unit of Nutrition and Cancer, Cancer Epidemiology Research Programme, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain., Spanien
  • Miguel Rodríguez-Barranco, Escuela Andaluza de Salud Pública. Instituto de Investigación Biosanitaria ibs. GRANADA. Hospitales Universitarios de Granada/Universidad de Granada, Granada, Spain., Spanien
  • Miren Dorronsoro, Public Health Division of Gipuzkoa, BioDonostia Research Institute, Health Department of Basque Region, Avenida de Navarra, 4-20013 Donostia, San Sebastian, Spain., Spanien
  • Maria-Dolores Chirlaque, Department of Epidemiology, Regional Health Council, IMIB-Arrixaca, Murcia University, Spain; CIBER in Epidemiology and Public Health (CIBERESP), Madrid, Spain., Spanien
  • Aurelio Barricarte, IdiSNA, Navarra Institute for Health Research, Pamplona, Spain., Spanien
  • Aurora Perez-Cornago, Cancer Epidemiology Unit, Nuffield Department of Population Health University of Oxford, United Kingdom., Storbritannien
  • Antonia Trichopoulou, WHO Collaborating Centre for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Greece., Grækenland
  • Christina Bamia, WHO Collaborating Centre for Nutrition and Health, Unit of Nutritional Epidemiology and Nutrition in Public Health, Dept. of Hygiene, Epidemiology and Medical Statistics, School of Medicine, National and Kapodistrian University of Athens, Greece., Grækenland
  • Pagona Lagiou, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA., USA
  • Giovanna Masala, Cancer Risk Factors and Lifestyle Epidemiology Unit, Institute for cancer research, prevention and clinical network (ISPRO), Florence, Italy., Italien
  • Sara Grioni, 12 Epidemiology and Prevention Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milan, Italy., Italien
  • Rosario Tumino, Cancer Registry and Histopathology Department, Civic-M.P.Arezzo Hospital, ASP, 97100 Ragusa, Italy. rtumino@tin.it., Italien
  • Carlotta Sacerdote, Unit of Cancer Epidemiology, Citta' della Salute e della Scienza Hospital-University of Turin and Centre for Cancer Prevention (CPO), Turin, Italy; Human Genetics Foundation (HuGeF), Turin, Italy., Italien
  • Amalia Mattiello, Dipartimento di Medicina Clinica e Chirurgia, Federico II University, Naples, Italy., Italien
  • Bas Bueno-de-Mesquita, Julius Centre University of Malaya, Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia;, Malaysia
  • Roel Vermeulen, Institute for Risk Assessment Sciences, Utrecht University, Holland
  • Carla Van Gils, Department of Epidemiology, Julius Centre Research Program Cancer, UMC Utrecht., Holland
  • Hanna Nyström, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Sverige
  • Martin Rutegård, Department of Surgical and Perioperative Sciences, Umeå University, Umeå, Sweden., Sverige
  • Dagfinn Aune, Department of Nutrition, Bjørknes University College, Oslo, Norway., Norge
  • Elio Riboli, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien
  • Amanda J Cross, School of Public Health, Imperial College London, London, United Kingdom., Storbritannien

Gallstones, a common gastrointestinal condition, can lead to several digestive complications and can result in inflammation. Risk factors for gallstones include obesity, diabetes, smoking and physical inactivity, all of which are known risk factors for colorectal cancer (CRC), as is inflammation. However, it is unclear whether gallstones are a risk factor for CRC. We examined the association between history of gallstones and CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, a prospective cohort of over half a million participants from ten European countries. History of gallstones was assessed at baseline using a self-reported questionnaire. The analytic cohort included 334,986 participants; a history of gallstones was reported by 3,917 men and 19,836 women, and incident CRC was diagnosed among 1,832 men and 2,178 women (mean follow-up: 13.6 years). Hazard ratios (HR) and 95% confidence intervals (CI) for the association between gallstones and CRC were estimated using Cox proportional hazards regression models, stratified by sex, study centre, and age at recruitment. The models were adjusted for body mass index, diabetes, alcohol intake, and physical activity. A positive, marginally significant association was detected between gallstones and CRC among women in multivariable analyses (HR=1.14, 95%CI 0.99-1.31, p=0.077). The relationship between gallstones and CRC among men was inverse but not significant (HR=0.81, 95%CI 0.63-1.04, p=0.10). Additional adjustment for details of reproductive history or waist circumference yielded minimal changes to the observed associations. Further research is required to confirm the nature of the association between gallstones and CRC by sex. This article is protected by copyright. All rights reserved.

OriginalsprogEngelsk
TidsskriftInternational Journal of Cancer
Vol/bind145
Nummer6
Sider (fra-til)1510-1516
Antal sider7
ISSN0020-7136
DOI
StatusUdgivet - 15 sep. 2019

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This article is protected by copyright. All rights reserved.

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