Functional studies of interferon λ4 and the high affinity chain of the type III interferon receptor complex

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 4 sep. 2015

Note vedr. afhandling

Upon infection of the liver with the hepatitis C virus, the majority of infected individuals show no signs of infection, which silently progresses into a chronic state, impairing liver function and provoking the development of liver cancer. The ability to clear this infection differs between patients and is strongly dependent on their genetic background, in particular on one gene, which encodes an antiviral protein called interferon-λ4.

During her PhD studies, Ewa Terczyńska-Dyla investigated the function of interferon-λ4 to determine its role in disease development. Surprisingly, the research shows that patients possessing the more active form of interferon-λ4 are more likely to fail the treatment than those individuals who do not have interferon-λ4 or those who only possess the less active form. These new research findings demonstrate that even an antiviral protein that is meant to help combat the infection can have a detrimental effect in certain diseases. The study contributes to the understanding of how our immune system fights the viral infection and helps to identify patients who are difficult to cure and who therefore require special treatment.

The PhD degree was completed at the Department of Molecular Biology and Genetics, Science and Technology, Aarhus University.

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