Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications

TY - JOUR

T1 - Functional Prototissues Using Artificial Cells as Building Blocks and Their Biomedical Applications

AU - Zhang, Xiangxiang

AU - Li, Chao

AU - Yang, Boyu

AU - Wang, Weichen

AU - Zhao, Jingjing

AU - Zhao, Wan

AU - Dong, Mingdong

AU - Han, Xiaojun

PY - 2024/10/1

Y1 - 2024/10/1

N2 - The construction of living systems from the bottom-up helps to explore the complex processes of life and to understand their working mechanism. Prototissues, constructed using artificial cells as building blocks, mimic life systems at a high-order tissue level, whilst artificial cells usually mimic living cells at the individual cell level. The 3D biomimetic prototissues demonstrate exceptional performances and collective functions, which reveal the working mechanisms of living tissues and hold promising potential for biomedical applications. This review systematically summarized the research progress of the field of prototissues. The engineering methods for fabricating two types of prototissues are introduced first, followed by the functions of prototissues including collective behaviors and signal communications, as well as their biomedical applications. The challenges and future trends are proposed at the end of the paper.

AB - The construction of living systems from the bottom-up helps to explore the complex processes of life and to understand their working mechanism. Prototissues, constructed using artificial cells as building blocks, mimic life systems at a high-order tissue level, whilst artificial cells usually mimic living cells at the individual cell level. The 3D biomimetic prototissues demonstrate exceptional performances and collective functions, which reveal the working mechanisms of living tissues and hold promising potential for biomedical applications. This review systematically summarized the research progress of the field of prototissues. The engineering methods for fabricating two types of prototissues are introduced first, followed by the functions of prototissues including collective behaviors and signal communications, as well as their biomedical applications. The challenges and future trends are proposed at the end of the paper.

KW - artificial cell

KW - collective behavior

KW - prototissue

KW - signal communication

UR - http://www.scopus.com/inward/record.url?scp=85196431442&partnerID=8YFLogxK

U2 - 10.1002/adfm.202405823

DO - 10.1002/adfm.202405823

M3 - Review

AN - SCOPUS:85196431442

SN - 1616-301X

VL - 34

JO - Advanced Functional Materials

JF - Advanced Functional Materials

IS - 40

M1 - 2405823

ER -