Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

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Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography. / Ørntoft, Nikolaj; Frisch, Kim; Ott, Peter; Keiding, Susanne; Sørensen, Michael.

I: B B A - Molecular Basis of Disease, Bind 1864, Nr. 4, Part B, 04.2018, s. 1240-1244.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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@article{222edc4ba104485ab382d7be254f95be,
title = "Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography",
abstract = "Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.",
keywords = "Journal Article, Review",
author = "Nikolaj {\O}rntoft and Kim Frisch and Peter Ott and Susanne Keiding and Michael S{\o}rensen",
note = "Copyright {\textcopyright} 2017 Elsevier B.V. All rights reserved.",
year = "2018",
month = apr,
doi = "10.1016/j.bbadis.2017.11.016",
language = "English",
volume = "1864",
pages = "1240--1244",
journal = "B B A - Molecular Basis of Disease",
issn = "0925-4439",
publisher = "Elsevier BV",
number = "4, Part B",

}

RIS

TY - JOUR

T1 - Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

AU - Ørntoft, Nikolaj

AU - Frisch, Kim

AU - Ott, Peter

AU - Keiding, Susanne

AU - Sørensen, Michael

N1 - Copyright © 2017 Elsevier B.V. All rights reserved.

PY - 2018/4

Y1 - 2018/4

N2 - Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

AB - Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

KW - Journal Article

KW - Review

U2 - 10.1016/j.bbadis.2017.11.016

DO - 10.1016/j.bbadis.2017.11.016

M3 - Review

C2 - 29197661

VL - 1864

SP - 1240

EP - 1244

JO - B B A - Molecular Basis of Disease

JF - B B A - Molecular Basis of Disease

SN - 0925-4439

IS - 4, Part B

ER -