Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

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Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

OriginalsprogEngelsk
TidsskriftB B A - Molecular Basis of Disease
Vol/bind1864
Nummer4, Part B
Sider (fra-til)1240-1244
Antal sider5
ISSN0925-4439
DOI
StatusUdgivet - apr. 2018

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