Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Nikolaj Ørntoft; Kim Frisch; Peter Ott; Susanne Keiding; Michael Sørensen

doi:10.1016/j.bbadis.2017.11.016

Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Nikolaj Ørntoft, Kim Frisch, Peter Ott, Susanne Keiding, Michael Sørensen

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

9 Citationer (Scopus)

Abstract

Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

Originalsprog	Engelsk
Tidsskrift	B B A - Molecular Basis of Disease
Vol/bind	1864
Nummer	4, Part B
Sider (fra-til)	1240-1244
Antal sider	5
ISSN	0925-4439
DOI	https://doi.org/10.1016/j.bbadis.2017.11.016 https://doi.org/10.1016/j.bbadis.2017.11.016
Status	Udgivet - apr. 2018

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Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography. / Ørntoft, Nikolaj; Frisch, Kim ; Ott, Peter et al.
I: B B A - Molecular Basis of Disease, Bind 1864, Nr. 4, Part B, 04.2018, s. 1240-1244.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

AU - Ørntoft, Nikolaj

AU - Frisch, Kim

AU - Ott, Peter

AU - Keiding, Susanne

AU - Sørensen, Michael

PY - 2018/4

Y1 - 2018/4

N2 - Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

AB - Positron emission tomography (PET) with 11C-cholylsarcosine (11C-CSar), a radiolabelled synthetic N-methylglycine (sarcosine) conjugate of cholic acid, is a novel molecular imaging technique that enables quantitative assessment of the individual transport steps involved in hepatic secretion of conjugated bile acids. Here, we present the method and discuss its potential clinical and scientific applications based on findings in the first human study of healthy subjects and patients with cholestasis. We also present a clinical example of a patient studied during and six months after an episode of drug-induced cholestatic liver injury.

KW - Journal Article

KW - Review

UR - http://www.scopus.com/inward/record.url?scp=85038886546&partnerID=8YFLogxK

U2 - 10.1016/j.bbadis.2017.11.016

DO - 10.1016/j.bbadis.2017.11.016

M3 - Journal article

C2 - 29197661

SN - 0925-4439

VL - 1864

SP - 1240

EP - 1244

JO - B B A - Molecular Basis of Disease

JF - B B A - Molecular Basis of Disease

IS - 4, Part B

ER -

Functional assessment of hepatobiliary secretion by 11C-cholylsarcosine positron emission tomography

Abstract

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