Formulation and anti-neurotoxic activity of baicalein-incorporating neutral nanoliposome

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  • Farhang Aliakbari, Semnan University of Medical Sciences, National Institute of Genetic Engineering and Biotechnology
  • ,
  • Ali Akbar Shabani, Semnan University of Medical Sciences, Iran
  • Hassan Bardania, Yasuj University of Medical Sciences
  • ,
  • Hossein Mohammad-Beigi
  • Amir Tayaranian Marvian, National Institute of Genetic Engineering and Biotechnology
  • ,
  • Faezeh Dehghani Esmatabad, National Institute of Genetic Engineering and Biotechnology, Iran
  • Abbas Ali Vafaei, Semnan University of Medical Sciences, Iran
  • Seyed Abbas Shojaosadati, Tarbiat Modares University
  • ,
  • Ali Akbar Saboury, University of Tehran, Iran
  • Gunna Christiansen
  • Daniel E Otzen
  • Dina Morshedi, National Institute of Genetic Engineering and Biotechnology, Iran

Despite extensive studies of the effects of herbal-derived small molecules in the biopharmaceutical and biomedical sciences, their low solubility and stability remain a challenge. Here we focus on baicalein, a small molecule showing potential against neurodegenerative diseases such as Parkinson's and Alzheimer's. However, therapeutic usage in vivo is challenged by low solubility and stability. To address this we have applied neutrally-charged nanoliposome (NLP) as carrier for baicalein. Baicalein was incorporated into NLP to form NLP-Ba at molar baicalain:lipid ratios of up to 1:3, giving a drug entrapment efficiency of 96.71%, slow release of approximately 22% after a week and increased baicalein stability up to 27%. Ascorbic acid increased baicalein's stability further, particularly when incorporated in NLP where baicalein stability intensified by 53% in NLP-Ba. Moreover, NLP-Ba did not show significant cytotoxic effects against neurons; rather, showed considerable protective effect against reactive oxygen species. In addition, NLP promoted internalization of baicalein into cells, showing good biocompatibility. We conclude that NLP-Ba can enhance baicalein's therapeutic potential in neurodegenerative diseases.

OriginalsprogEngelsk
TidsskriftColloids and surfaces. B, Biointerfaces
Vol/bind161
Sider (fra-til)578-587
Antal sider10
ISSN0927-7765
DOI
StatusUdgivet - 1 jan. 2018

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