Formation of i-motifs from acyclic (l)-threoninol nucleic acids

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Acyclic (l)-threoninol nucleic acids ((l)-aTNA) containing poly-cytosines are prepared and investigated at various pH values, revealing the formation of a highly stable structure at lower pH that have the characteristics of an i-motif. Depending on the sequence, the aTNA forms inter-, bi- and intra-molecular i-motif structures. Pyrene was conjugated to aTNA sequences and both monomeric and excimer fluorescence were efficiently quenched by the i-motif structures and thus demonstrated that the aTNA i-motif can serve as a pH switch.

OriginalsprogEngelsk
TidsskriftOrganic & Biomolecular Chemistry
Vol/bind17
Nummer33
Sider (fra-til)7655-7659
Antal sider5
ISSN1477-0520
DOI
StatusUdgivet - sep. 2019

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