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Follicular Dendritic Cells Modulate Germinal Center B Cell Diversity through FcγRIIB

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

  • Cees E. van der Poel, Boston Children's Hospital
  • ,
  • Goran Bajic, Boston Children's Hospital
  • ,
  • Charles W. Macaulay, Boston Children's Hospital, Boston University
  • ,
  • Theo van den Broek, Boston Children's Hospital
  • ,
  • Christian D. Ellson, GlaxoSmithKline
  • ,
  • Gerben Bouma, GlaxoSmithKline
  • ,
  • Gabriel D. Victora, Rockefeller University
  • ,
  • Søren E. Degn
  • Michael C. Carroll, Boston Children's Hospital

van der Poel et al. show that follicular dendritic cells (FDCs) can regulate germinal center diversity through FcγRIIB. In the absence of this receptor, germinal centers appear more diverse. In addition, the loss of FcγRIIB on FDCs leads to the persistence of IgM clones with decreased levels of somatic hypermutation.

OriginalsprogEngelsk
TidsskriftCell Reports
Vol/bind29
Nummer9
Sider (fra-til)2745-2755.e4
Antal sider11
ISSN2211-1247
DOI
StatusUdgivet - 2019

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