Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery

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Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery. / Bay, Vibeke; Happ, Denise F; Ardalan, Maryam; Quist, Alexandra; Oggiano, Florian; Chumak, Tetyana; Hansen, Kasper; Ding, Ming; Mallard, Carina; Tasker, R Andrew; Wegener, Gregers.

I: Brain Research, Bind 1737, 146797, 06.2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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Bay, Vibeke ; Happ, Denise F ; Ardalan, Maryam ; Quist, Alexandra ; Oggiano, Florian ; Chumak, Tetyana ; Hansen, Kasper ; Ding, Ming ; Mallard, Carina ; Tasker, R Andrew ; Wegener, Gregers. / Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery. I: Brain Research. 2020 ; Bind 1737.

Bibtex

@article{f358b51da21f41499a901add3ebe0b9a,
title = "Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery",
abstract = "BACKGROUND: Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The underlying mechanisms linking depression and stroke remain unclear. Preclinical models may provide novel insights, but models reflecting both conditions are lacking.METHODS: In this study, we investigated the effects of a 45-min transient middle cerebral artery occlusion (MCAo) on infarct size in male adult Flinders Sensitive Line rats, a genetic animal model of depression, and their control strains Flinders Resistant Line and Sprague-Dawley rats. Infarct size was assessed by tetrazolium chloride (TTC) and microtubule-associated protein 2 (MAP2) staining after 48 h of reperfusion. Angiograms of the vascular structure of na{\"i}ve animals were produced with a µ-CT scanner.RESULTS: Both Flinders strains had significantly smaller infarcts following MCAo compared to Sprague-Dawley rats. This effect does not appear to be due to changes in cerebrovascular architecture, as indicated by an initial exploration of vascular organization using angiograms, or body temperature regulation.CONCLUSIONS: Our study suggests that the rat strain does not influence infarct volumes following MCAo.",
keywords = "Depression, Flinders sensitive line, MCAo, Stroke, TTC, METAANALYSIS, RISK, STROKE PATIENTS, DEPRESSIVE SYMPTOMS, MAJOR DEPRESSION, MODEL, INFLAMMATION, PREDICTORS, CALCIFICATION, PROGRESSION",
author = "Vibeke Bay and Happ, {Denise F} and Maryam Ardalan and Alexandra Quist and Florian Oggiano and Tetyana Chumak and Kasper Hansen and Ming Ding and Carina Mallard and Tasker, {R Andrew} and Gregers Wegener",
year = "2020",
month = jun,
doi = "10.1016/j.brainres.2020.146797",
language = "English",
volume = "1737",
journal = "Brain Research Reviews",
issn = "0165-0173",
publisher = "Elsevier BV",

}

RIS

TY - JOUR

T1 - Flinders sensitive line rats are resistant to infarction following transient occlusion of the middle cerebral artery

AU - Bay, Vibeke

AU - Happ, Denise F

AU - Ardalan, Maryam

AU - Quist, Alexandra

AU - Oggiano, Florian

AU - Chumak, Tetyana

AU - Hansen, Kasper

AU - Ding, Ming

AU - Mallard, Carina

AU - Tasker, R Andrew

AU - Wegener, Gregers

PY - 2020/6

Y1 - 2020/6

N2 - BACKGROUND: Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The underlying mechanisms linking depression and stroke remain unclear. Preclinical models may provide novel insights, but models reflecting both conditions are lacking.METHODS: In this study, we investigated the effects of a 45-min transient middle cerebral artery occlusion (MCAo) on infarct size in male adult Flinders Sensitive Line rats, a genetic animal model of depression, and their control strains Flinders Resistant Line and Sprague-Dawley rats. Infarct size was assessed by tetrazolium chloride (TTC) and microtubule-associated protein 2 (MAP2) staining after 48 h of reperfusion. Angiograms of the vascular structure of naïve animals were produced with a µ-CT scanner.RESULTS: Both Flinders strains had significantly smaller infarcts following MCAo compared to Sprague-Dawley rats. This effect does not appear to be due to changes in cerebrovascular architecture, as indicated by an initial exploration of vascular organization using angiograms, or body temperature regulation.CONCLUSIONS: Our study suggests that the rat strain does not influence infarct volumes following MCAo.

AB - BACKGROUND: Depression is a common complication of stroke and increases the risk of mortality and disability. Pre-stroke depression is a possible risk factor for stroke and has also been linked to adverse outcomes. The underlying mechanisms linking depression and stroke remain unclear. Preclinical models may provide novel insights, but models reflecting both conditions are lacking.METHODS: In this study, we investigated the effects of a 45-min transient middle cerebral artery occlusion (MCAo) on infarct size in male adult Flinders Sensitive Line rats, a genetic animal model of depression, and their control strains Flinders Resistant Line and Sprague-Dawley rats. Infarct size was assessed by tetrazolium chloride (TTC) and microtubule-associated protein 2 (MAP2) staining after 48 h of reperfusion. Angiograms of the vascular structure of naïve animals were produced with a µ-CT scanner.RESULTS: Both Flinders strains had significantly smaller infarcts following MCAo compared to Sprague-Dawley rats. This effect does not appear to be due to changes in cerebrovascular architecture, as indicated by an initial exploration of vascular organization using angiograms, or body temperature regulation.CONCLUSIONS: Our study suggests that the rat strain does not influence infarct volumes following MCAo.

KW - Depression

KW - Flinders sensitive line

KW - MCAo

KW - Stroke

KW - TTC

KW - METAANALYSIS

KW - RISK

KW - STROKE PATIENTS

KW - DEPRESSIVE SYMPTOMS

KW - MAJOR DEPRESSION

KW - MODEL

KW - INFLAMMATION

KW - PREDICTORS

KW - CALCIFICATION

KW - PROGRESSION

U2 - 10.1016/j.brainres.2020.146797

DO - 10.1016/j.brainres.2020.146797

M3 - Journal article

C2 - 32194078

VL - 1737

JO - Brain Research Reviews

JF - Brain Research Reviews

SN - 0165-0173

M1 - 146797

ER -