Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. / Bondonno, Catherine P; Bondonno, Nicola P; Dalgaard, Frederik; Murray, Kevin; Gardener, Samantha L; Martins, Ralph N; Rainey-Smith, Stephanie R; Cassidy, Aedín; Lewis, Joshua R; Croft, Kevin D; Kyrø, Cecilie; Gislason, Gunnar; Scalbert, Augustin; Tjønneland, Anne; Overvad, Kim; Hodgson, Jonathan M.

I: Alzheimer's and Dementia: Translational Research and Clinical Interventions, Bind 7, Nr. 1, e12175, 05.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Bondonno, CP, Bondonno, NP, Dalgaard, F, Murray, K, Gardener, SL, Martins, RN, Rainey-Smith, SR, Cassidy, A, Lewis, JR, Croft, KD, Kyrø, C, Gislason, G, Scalbert, A, Tjønneland, A, Overvad, K & Hodgson, JM 2021, 'Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort', Alzheimer's and Dementia: Translational Research and Clinical Interventions, bind 7, nr. 1, e12175. https://doi.org/10.1002/trc2.12175

APA

Bondonno, C. P., Bondonno, N. P., Dalgaard, F., Murray, K., Gardener, S. L., Martins, R. N., Rainey-Smith, S. R., Cassidy, A., Lewis, J. R., Croft, K. D., Kyrø, C., Gislason, G., Scalbert, A., Tjønneland, A., Overvad, K., & Hodgson, J. M. (2021). Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 7(1), [e12175]. https://doi.org/10.1002/trc2.12175

CBE

Bondonno CP, Bondonno NP, Dalgaard F, Murray K, Gardener SL, Martins RN, Rainey-Smith SR, Cassidy A, Lewis JR, Croft KD, Kyrø C, Gislason G, Scalbert A, Tjønneland A, Overvad K, Hodgson JM. 2021. Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 7(1):Article e12175. https://doi.org/10.1002/trc2.12175

MLA

Bondonno, Catherine P o.a.. "Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort". Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2021. 7(1). https://doi.org/10.1002/trc2.12175

Vancouver

Bondonno CP, Bondonno NP, Dalgaard F, Murray K, Gardener SL, Martins RN o.a. Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2021 maj;7(1). e12175. https://doi.org/10.1002/trc2.12175

Author

Bondonno, Catherine P ; Bondonno, Nicola P ; Dalgaard, Frederik ; Murray, Kevin ; Gardener, Samantha L ; Martins, Ralph N ; Rainey-Smith, Stephanie R ; Cassidy, Aedín ; Lewis, Joshua R ; Croft, Kevin D ; Kyrø, Cecilie ; Gislason, Gunnar ; Scalbert, Augustin ; Tjønneland, Anne ; Overvad, Kim ; Hodgson, Jonathan M. / Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort. I: Alzheimer's and Dementia: Translational Research and Clinical Interventions. 2021 ; Bind 7, Nr. 1.

Bibtex

@article{e3cb4d21c86f4198b96eb58355562770,
title = "Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort",
abstract = "Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in {"}ever{"} smokers than in {"}never{"} smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in {"}ever{"} smokers and those who were {"}normal{"} to {"}overweight{"} versus {"}never{"} smokers or those who were {"}obese,{"} respectively.Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.",
keywords = "Alzheimer's disease, dementia, flavonoid subclasses, flavonoids, prospective study, vascular dementia",
author = "Bondonno, {Catherine P} and Bondonno, {Nicola P} and Frederik Dalgaard and Kevin Murray and Gardener, {Samantha L} and Martins, {Ralph N} and Rainey-Smith, {Stephanie R} and Aed{\'i}n Cassidy and Lewis, {Joshua R} and Croft, {Kevin D} and Cecilie Kyr{\o} and Gunnar Gislason and Augustin Scalbert and Anne Tj{\o}nneland and Kim Overvad and Hodgson, {Jonathan M}",
note = "{\textcopyright} 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.",
year = "2021",
month = may,
doi = "10.1002/trc2.12175",
language = "English",
volume = "7",
journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",
issn = "2352-8737",
publisher = "Elsevier Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

AU - Bondonno, Catherine P

AU - Bondonno, Nicola P

AU - Dalgaard, Frederik

AU - Murray, Kevin

AU - Gardener, Samantha L

AU - Martins, Ralph N

AU - Rainey-Smith, Stephanie R

AU - Cassidy, Aedín

AU - Lewis, Joshua R

AU - Croft, Kevin D

AU - Kyrø, Cecilie

AU - Gislason, Gunnar

AU - Scalbert, Augustin

AU - Tjønneland, Anne

AU - Overvad, Kim

AU - Hodgson, Jonathan M

N1 - © 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.

PY - 2021/5

Y1 - 2021/5

N2 - Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in "ever" smokers than in "never" smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in "ever" smokers and those who were "normal" to "overweight" versus "never" smokers or those who were "obese," respectively.Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.

AB - Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in "ever" smokers than in "never" smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in "ever" smokers and those who were "normal" to "overweight" versus "never" smokers or those who were "obese," respectively.Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.

KW - Alzheimer's disease

KW - dementia

KW - flavonoid subclasses

KW - flavonoids

KW - prospective study

KW - vascular dementia

U2 - 10.1002/trc2.12175

DO - 10.1002/trc2.12175

M3 - Journal article

C2 - 34027025

VL - 7

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

SN - 2352-8737

IS - 1

M1 - e12175

ER -