Flavonoid intake and incident dementia in the Danish Diet, Cancer, and Health cohort

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

DOI

  • Catherine P Bondonno, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australien
  • Nicola P Bondonno, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Institute for Global Food SecurityQueen’s University Belfast, Belfast, Northern Ireland, Australien
  • Frederik Dalgaard, Department of Cardiology, Herlev-Gentofte Hospital, University Hospital Copenhagen, Herlev Ringvej 75, Herlev, Denmark., Danmark
  • Kevin Murray, School of Population and Global Health, University of Western Australia, Perth, WA, Australia., Australien
  • Samantha L Gardener, Centre of Excellence for Alzheimer's Disease Research & Care School of Medical and Health Sciences Edith Cowan University Joondalup Australia, Australien
  • Ralph N Martins, Centre of Excellence for Alzheimer's Disease Research & Care School of Medical and Health Sciences Edith Cowan University Joondalup Australia, Australian Alzheimer's Research Foundation, Perth, Department of Biomedical Sciences, Macquarie University, Sydney, Australien
  • Stephanie R Rainey-Smith, Centre of Excellence for Alzheimer's Disease Research & Care School of Medical and Health Sciences Edith Cowan University Joondalup Australia, Australian Alzheimer's Research Foundation, Perth, Australien
  • Aedín Cassidy, Institute for Global Food Security, Queen's University Belfast, Belfast, Northern Ireland., Storbritannien
  • Joshua R Lewis, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australien
  • Kevin D Croft, School of Biomedical Sciences, University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australien
  • Cecilie Kyrø, Danish Cancer Society Research Centre, Danish Cancer Society, Copenhagen, Denmark., Danmark
  • Gunnar Gislason, Department of Cardiology, Herlev-Gentofte Hospital, University Hospital Copenhagen, Herlev Ringvej 75, Herlev, Denmark., National Institute of Public Health, Southern Denmark University, DK-5230, Odense M, Denmark., Danish Heart Foundation, Danmark
  • Augustin Scalbert, International Agency for Research on Cancer, Lyon, France., Frankrig
  • Anne Tjønneland, Danish Cancer Society Research Center, Danish Cancer Society, Copenhagen, Denmark., Department of Public Health, University of Copenhagen, Copenhagen, Denmark, Danmark
  • Kim Overvad
  • Jonathan M Hodgson, School of Medical and Health Sciences, Edith Cowan University, Perth, Australia; School of Biomedical Sciences, The University of Western Australia, Royal Perth Hospital, Perth, Western Australia, Australia., Australien

Introduction: Prospective studies investigating flavonoid intake and dementia risk are scarce. The aims of this study were to examine associations between flavonoid intake and the risk of incident dementia and to investigate whether this association differs in the presence of lifestyle risk factors for dementia.

Methods: We examined associations in 55,985 participants of the Danish Diet, Cancer, and Health Study followed for 23 years. The Phenol-Explorer database was used to estimate flavonoid intakes. Information on incident dementia and dementia subtypes was obtained using Danish patient and prescription registries. Hazard ratios (HRs) were calculated using restricted cubic splines in multivariable-adjusted Cox proportional hazards models.

Results: For incident dementia, moderate compared to low intakes of flavonols (HR: 0.90 [0.82, 0.99]), flavanol oligo+polymers (HR: 0.87 [0.79, 0.96]), anthocyanins (HR: 0.84 [0.76, 0.93]), flavanones (HR: 0.89 [0.80, 0.99]), and flavones (HR: 0.85 [0.77, 0.95]) were associated with a lower risk. For vascular dementia, moderate intakes of flavonols (HR: 0.69 [0.53, 0.89]) and flavanol oligo + polymers (HR: 0.65 [0.51, 0.83]) were associated with lower risk. Flavonoid intakes were not significantly associated with Alzheimer's disease or unspecified dementia. The inverse association between total flavonoid intake and incident dementia was stronger in "ever" smokers than in "never" smokers and in those without hypercholesterolemia versus those with hypercholesteremia. Furthermore, the inverse association of vascular dementia with a moderate total flavonoid intake was stronger in "ever" smokers and those who were "normal" to "overweight" versus "never" smokers or those who were "obese," respectively.

Conclusion: A moderate intake of flavonoid-rich foods may help to reduce dementia risk.

OriginalsprogEngelsk
Artikelnummere12175
TidsskriftAlzheimer's and Dementia: Translational Research and Clinical Interventions
Vol/bind7
Nummer1
Antal sider16
DOI
StatusUdgivet - maj 2021

Bibliografisk note

© 2021 The Authors. Alzheimer's & Dementia: Translational Research & Clinical Interventions published by Wiley Periodicals, Inc. on behalf of Alzheimer's Association.

Se relationer på Aarhus Universitet Citationsformater

ID: 217276451