Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11

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Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. / Schulman, N F; Sahana, G; Iso-Touru, T; Lund, M S; Andersson-Eklund, L; Viitala, S M; Värv, S; Viinalass, H; Vilkki, J H.

I: Animal Genetics, Bind 40, Nr. 4, 2009, s. 509-515.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Schulman, NF, Sahana, G, Iso-Touru, T, Lund, MS, Andersson-Eklund, L, Viitala, SM, Värv, S, Viinalass, H & Vilkki, JH 2009, 'Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11', Animal Genetics, bind 40, nr. 4, s. 509-515. https://doi.org/10.1111/j.1365-2052.2009.01872.x

APA

Schulman, N. F., Sahana, G., Iso-Touru, T., Lund, M. S., Andersson-Eklund, L., Viitala, S. M., Värv, S., Viinalass, H., & Vilkki, J. H. (2009). Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. Animal Genetics, 40(4), 509-515. https://doi.org/10.1111/j.1365-2052.2009.01872.x

CBE

Schulman NF, Sahana G, Iso-Touru T, Lund MS, Andersson-Eklund L, Viitala SM, Värv S, Viinalass H, Vilkki JH. 2009. Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. Animal Genetics. 40(4):509-515. https://doi.org/10.1111/j.1365-2052.2009.01872.x

MLA

Vancouver

Author

Schulman, N F ; Sahana, G ; Iso-Touru, T ; Lund, M S ; Andersson-Eklund, L ; Viitala, S M ; Värv, S ; Viinalass, H ; Vilkki, J H. / Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11. I: Animal Genetics. 2009 ; Bind 40, Nr. 4. s. 509-515.

Bibtex

@article{0a97b080410811ddb005000ea68e967b,
title = "Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11",
abstract = "Quantitative trait loci (QTL) affecting clinical mastitis (CM) and somatic cell score (SCS) were mapped on bovine chromosome 11. The mapping population consisted of 14 grandsire families belonging to three Nordic red cattle breeds: Finnish Ayrshire (FA), Swedish Red and White (SRB) and Danish Red. The families had previously been shown to segregate for udder health QTL. A total of 524 progeny tested bulls were included in the analysis. A linkage map including 33 microsatellite and five SNP markers was constructed. We performed combined linkage disequilibrium and linkage analysis (LDLA) using the whole data set. Further analyses were performed for FA and SRB separately to study the origin of the identified QTL/haplotype and to examine if it was common in both populations. Finally, different two-trait models were fitted. These postulated either a pleiotropic QTL affecting both traits; two linked QTL, each affecting one trait; or one QTL affecting a single trait. A QTL affecting CM was fine-mapped. In FA, a haplotype having a strong association with a high negative effect on mastitis resistance was identified. The mapping precision of an earlier detected SCS-QTL was not improved by the LDLA analysis because of lack of linkage disequilibrium between the markers used and the QTL in the region",
keywords = "dairy cattle, fine-mapping, mastitis, somatic cell score",
author = "Schulman, {N F} and G Sahana and T Iso-Touru and Lund, {M S} and L Andersson-Eklund and Viitala, {S M} and S V{\"a}rv and H Viinalass and Vilkki, {J H}",
year = "2009",
doi = "10.1111/j.1365-2052.2009.01872.x",
language = "English",
volume = "40",
pages = "509--515",
journal = "Animal Genetics",
issn = "0268-9146",
publisher = "Wiley-Blackwell Publishing Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11

AU - Schulman, N F

AU - Sahana, G

AU - Iso-Touru, T

AU - Lund, M S

AU - Andersson-Eklund, L

AU - Viitala, S M

AU - Värv, S

AU - Viinalass, H

AU - Vilkki, J H

PY - 2009

Y1 - 2009

N2 - Quantitative trait loci (QTL) affecting clinical mastitis (CM) and somatic cell score (SCS) were mapped on bovine chromosome 11. The mapping population consisted of 14 grandsire families belonging to three Nordic red cattle breeds: Finnish Ayrshire (FA), Swedish Red and White (SRB) and Danish Red. The families had previously been shown to segregate for udder health QTL. A total of 524 progeny tested bulls were included in the analysis. A linkage map including 33 microsatellite and five SNP markers was constructed. We performed combined linkage disequilibrium and linkage analysis (LDLA) using the whole data set. Further analyses were performed for FA and SRB separately to study the origin of the identified QTL/haplotype and to examine if it was common in both populations. Finally, different two-trait models were fitted. These postulated either a pleiotropic QTL affecting both traits; two linked QTL, each affecting one trait; or one QTL affecting a single trait. A QTL affecting CM was fine-mapped. In FA, a haplotype having a strong association with a high negative effect on mastitis resistance was identified. The mapping precision of an earlier detected SCS-QTL was not improved by the LDLA analysis because of lack of linkage disequilibrium between the markers used and the QTL in the region

AB - Quantitative trait loci (QTL) affecting clinical mastitis (CM) and somatic cell score (SCS) were mapped on bovine chromosome 11. The mapping population consisted of 14 grandsire families belonging to three Nordic red cattle breeds: Finnish Ayrshire (FA), Swedish Red and White (SRB) and Danish Red. The families had previously been shown to segregate for udder health QTL. A total of 524 progeny tested bulls were included in the analysis. A linkage map including 33 microsatellite and five SNP markers was constructed. We performed combined linkage disequilibrium and linkage analysis (LDLA) using the whole data set. Further analyses were performed for FA and SRB separately to study the origin of the identified QTL/haplotype and to examine if it was common in both populations. Finally, different two-trait models were fitted. These postulated either a pleiotropic QTL affecting both traits; two linked QTL, each affecting one trait; or one QTL affecting a single trait. A QTL affecting CM was fine-mapped. In FA, a haplotype having a strong association with a high negative effect on mastitis resistance was identified. The mapping precision of an earlier detected SCS-QTL was not improved by the LDLA analysis because of lack of linkage disequilibrium between the markers used and the QTL in the region

KW - dairy cattle

KW - fine-mapping

KW - mastitis

KW - somatic cell score

U2 - 10.1111/j.1365-2052.2009.01872.x

DO - 10.1111/j.1365-2052.2009.01872.x

M3 - Journal article

C2 - 19397517

VL - 40

SP - 509

EP - 515

JO - Animal Genetics

JF - Animal Genetics

SN - 0268-9146

IS - 4

ER -