Fine mapping of quantitative trait loci for mastitis resistance on bovine chromosome 11

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  • N F Schulman, MTT Agrifood Research Finland, Finland
  • G Sahana
  • T Iso-Touru, MTT, Agrifood Research Finland, Finland
  • M S Lund
  • L Andersson-Eklund, Dept. of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Sverige
  • S M Viitala, MTT Agrifood Research Finland, Finland
  • S Värv, Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Estland
  • H Viinalass, Institute of Veterinary Medicine and Animal Sciences, Estonian University of Life Sciences, Estland
  • J H Vilkki, MTT Agrifood Research Finland, Finland
  • Biostatistik
  • Institut for Genetik og Bioteknologi
Quantitative trait loci (QTL) affecting clinical mastitis (CM) and somatic cell score (SCS) were mapped on bovine chromosome 11. The mapping population consisted of 14 grandsire families belonging to three Nordic red cattle breeds: Finnish Ayrshire (FA), Swedish Red and White (SRB) and Danish Red. The families had previously been shown to segregate for udder health QTL. A total of 524 progeny tested bulls were included in the analysis. A linkage map including 33 microsatellite and five SNP markers was constructed. We performed combined linkage disequilibrium and linkage analysis (LDLA) using the whole data set. Further analyses were performed for FA and SRB separately to study the origin of the identified QTL/haplotype and to examine if it was common in both populations. Finally, different two-trait models were fitted. These postulated either a pleiotropic QTL affecting both traits; two linked QTL, each affecting one trait; or one QTL affecting a single trait. A QTL affecting CM was fine-mapped. In FA, a haplotype having a strong association with a high negative effect on mastitis resistance was identified. The mapping precision of an earlier detected SCS-QTL was not improved by the LDLA analysis because of lack of linkage disequilibrium between the markers used and the QTL in the region
Udgivelsesdato: August
OriginalsprogEngelsk
TidsskriftAnimal Genetics
Vol/bind40
Nummer4
Sider (fra-til)509-515
Antal sider7
ISSN0268-9146
DOI
StatusUdgivet - 2009

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