Fighting Thyroid Cancer with Microgravity Research

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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Fighting Thyroid Cancer with Microgravity Research. / Krüger, Marcus; Melnik, Daniela; Kopp, Sascha; Buken, Christoph; Sahana, Jayashree; Bauer, Johann; Wehland, Markus; Hemmersbach, Ruth; Corydon, Thomas J; Infanger, Manfred; Grimm, Daniela.

I: International Journal of Molecular Sciences, Bind 20, Nr. 10, 24.05.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

Harvard

Krüger, M, Melnik, D, Kopp, S, Buken, C, Sahana, J, Bauer, J, Wehland, M, Hemmersbach, R, Corydon, TJ, Infanger, M & Grimm, D 2019, 'Fighting Thyroid Cancer with Microgravity Research', International Journal of Molecular Sciences, bind 20, nr. 10. https://doi.org/10.3390/ijms20102553

APA

Krüger, M., Melnik, D., Kopp, S., Buken, C., Sahana, J., Bauer, J., ... Grimm, D. (2019). Fighting Thyroid Cancer with Microgravity Research. International Journal of Molecular Sciences, 20(10). https://doi.org/10.3390/ijms20102553

CBE

Krüger M, Melnik D, Kopp S, Buken C, Sahana J, Bauer J, Wehland M, Hemmersbach R, Corydon TJ, Infanger M, Grimm D. 2019. Fighting Thyroid Cancer with Microgravity Research. International Journal of Molecular Sciences. 20(10). https://doi.org/10.3390/ijms20102553

MLA

Krüger, Marcus o.a.. "Fighting Thyroid Cancer with Microgravity Research". International Journal of Molecular Sciences. 2019. 20(10). https://doi.org/10.3390/ijms20102553

Vancouver

Krüger M, Melnik D, Kopp S, Buken C, Sahana J, Bauer J o.a. Fighting Thyroid Cancer with Microgravity Research. International Journal of Molecular Sciences. 2019 maj 24;20(10). https://doi.org/10.3390/ijms20102553

Author

Krüger, Marcus ; Melnik, Daniela ; Kopp, Sascha ; Buken, Christoph ; Sahana, Jayashree ; Bauer, Johann ; Wehland, Markus ; Hemmersbach, Ruth ; Corydon, Thomas J ; Infanger, Manfred ; Grimm, Daniela. / Fighting Thyroid Cancer with Microgravity Research. I: International Journal of Molecular Sciences. 2019 ; Bind 20, Nr. 10.

Bibtex

@article{7b0a2a538ff4427bb1f93e53e535cff8,
title = "Fighting Thyroid Cancer with Microgravity Research",
abstract = "Microgravity in space or simulated by special ground-based devices provides an unusual but unique environment to study and influence tumour cell processes. By investigating thyroid cancer cells in microgravity for nearly 20 years, researchers got insights into tumour biology that had not been possible under normal laboratory conditions: adherently growing cancer cells detach from their surface and form three-dimensional structures. The cells included in these multicellular spheroids (MCS) were not only altered but behave also differently to those grown in flat sheets in normal gravity, more closely mimicking the conditions in the human body. Therefore, MCS became an invaluable model for studying metastasis and developing new cancer treatment strategies via drug targeting. Microgravity intervenes deeply in processes such as apoptosis and in structural changes involving the cytoskeleton and the extracellular matrix, which influence cell growth. Most interestingly, follicular thyroid cancer cells grown under microgravity conditions were shifted towards a less-malignant phenotype. Results from microgravity research can be used to rethink conventional cancer research and may help to pinpoint the cellular changes that cause cancer. This in turn could lead to novel therapies that will enhance the quality of life for patients or potentially develop new preventive countermeasures.",
author = "Marcus Kr{\"u}ger and Daniela Melnik and Sascha Kopp and Christoph Buken and Jayashree Sahana and Johann Bauer and Markus Wehland and Ruth Hemmersbach and Corydon, {Thomas J} and Manfred Infanger and Daniela Grimm",
year = "2019",
month = "5",
day = "24",
doi = "10.3390/ijms20102553",
language = "English",
volume = "20",
journal = "International Journal of Molecular Sciences (Online)",
issn = "1661-6596",
publisher = "MDPI AG",
number = "10",

}

RIS

TY - JOUR

T1 - Fighting Thyroid Cancer with Microgravity Research

AU - Krüger, Marcus

AU - Melnik, Daniela

AU - Kopp, Sascha

AU - Buken, Christoph

AU - Sahana, Jayashree

AU - Bauer, Johann

AU - Wehland, Markus

AU - Hemmersbach, Ruth

AU - Corydon, Thomas J

AU - Infanger, Manfred

AU - Grimm, Daniela

PY - 2019/5/24

Y1 - 2019/5/24

N2 - Microgravity in space or simulated by special ground-based devices provides an unusual but unique environment to study and influence tumour cell processes. By investigating thyroid cancer cells in microgravity for nearly 20 years, researchers got insights into tumour biology that had not been possible under normal laboratory conditions: adherently growing cancer cells detach from their surface and form three-dimensional structures. The cells included in these multicellular spheroids (MCS) were not only altered but behave also differently to those grown in flat sheets in normal gravity, more closely mimicking the conditions in the human body. Therefore, MCS became an invaluable model for studying metastasis and developing new cancer treatment strategies via drug targeting. Microgravity intervenes deeply in processes such as apoptosis and in structural changes involving the cytoskeleton and the extracellular matrix, which influence cell growth. Most interestingly, follicular thyroid cancer cells grown under microgravity conditions were shifted towards a less-malignant phenotype. Results from microgravity research can be used to rethink conventional cancer research and may help to pinpoint the cellular changes that cause cancer. This in turn could lead to novel therapies that will enhance the quality of life for patients or potentially develop new preventive countermeasures.

AB - Microgravity in space or simulated by special ground-based devices provides an unusual but unique environment to study and influence tumour cell processes. By investigating thyroid cancer cells in microgravity for nearly 20 years, researchers got insights into tumour biology that had not been possible under normal laboratory conditions: adherently growing cancer cells detach from their surface and form three-dimensional structures. The cells included in these multicellular spheroids (MCS) were not only altered but behave also differently to those grown in flat sheets in normal gravity, more closely mimicking the conditions in the human body. Therefore, MCS became an invaluable model for studying metastasis and developing new cancer treatment strategies via drug targeting. Microgravity intervenes deeply in processes such as apoptosis and in structural changes involving the cytoskeleton and the extracellular matrix, which influence cell growth. Most interestingly, follicular thyroid cancer cells grown under microgravity conditions were shifted towards a less-malignant phenotype. Results from microgravity research can be used to rethink conventional cancer research and may help to pinpoint the cellular changes that cause cancer. This in turn could lead to novel therapies that will enhance the quality of life for patients or potentially develop new preventive countermeasures.

U2 - 10.3390/ijms20102553

DO - 10.3390/ijms20102553

M3 - Review

VL - 20

JO - International Journal of Molecular Sciences (Online)

JF - International Journal of Molecular Sciences (Online)

SN - 1661-6596

IS - 10

ER -