Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark

Sidse Høyer; Uffe Heide-Jørgensen; Simon Kok Jensen; Mette Nørgaard; Cara Slagle; Stuart Goldstein; Christian Fynbo Christiansen

doi:10.1007/s00467-023-06246-9

Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark

Sidse Høyer^*, Uffe Heide-Jørgensen, Simon Kok Jensen, Mette Nørgaard, Cara Slagle, Stuart Goldstein, Christian Fynbo Christiansen

^*Corresponding author af dette arbejde

Institut for Klinisk Medicin - Klinisk Epidemiologisk Afdeling

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

BACKGROUND: We aimed to examine temporal changes in the annual rate of acute kidney injury (AKI) in Danish children and associated changes in patient characteristics including potential underlying risk factors.

METHODS: In this population-based cohort study, we used plasma creatinine measurements from Danish laboratory databases to identify AKI episodes in children aged 0-17 years from 2007 to 2021. For each child, the first AKI episode per calendar year was included. We estimated the annual crude and sex- and age-standardized AKI rate as the number of children with an AKI episode divided by the total number of children as reported by census numbers. Using Danish medical databases, we assessed patient characteristics including potential risk factors for AKI, such as use of nephrotoxic medication, surgery, sepsis, and perinatal factors.

RESULTS: In total, 14,200 children contributed with 16,345 AKI episodes over 15 years. The mean annual AKI rate was 148 (95% CI: 141-155) per 100,000 children. From 2007 to 2021, the annual AKI rate demonstrated minor year-to-year variability without any discernible overall trend. The highest AKI rate was recorded in 2007 at 174 (95% CI: 161-187) per 100,000 children, while the lowest rate occurred in 2012 at 129 (95% CI: 118-140) per 100,000 children. In 2021, the AKI rate was 148 (95% CI: 141-155) per 100,000 children. Characteristics of children with AKI were similar throughout the study period.

CONCLUSION: The rate of AKI among Danish children was stable from 2007 to 2021 with little variation in patient characteristics over time. A higher resolution version of the Graphical abstract is available as Supplementary information.

Originalsprog	Engelsk
Tidsskrift	Pediatric Nephrology
Vol/bind	39
Nummer	6
Sider (fra-til)	1917-1925
Antal sider	9
ISSN	0931-041X
DOI	https://doi.org/10.1007/s00467-023-06246-9
Status	Udgivet - jun. 2024

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10.1007/s00467-023-06246-9Licens: CC BY

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title = "Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark",

abstract = "BACKGROUND: We aimed to examine temporal changes in the annual rate of acute kidney injury (AKI) in Danish children and associated changes in patient characteristics including potential underlying risk factors.METHODS: In this population-based cohort study, we used plasma creatinine measurements from Danish laboratory databases to identify AKI episodes in children aged 0-17 years from 2007 to 2021. For each child, the first AKI episode per calendar year was included. We estimated the annual crude and sex- and age-standardized AKI rate as the number of children with an AKI episode divided by the total number of children as reported by census numbers. Using Danish medical databases, we assessed patient characteristics including potential risk factors for AKI, such as use of nephrotoxic medication, surgery, sepsis, and perinatal factors.RESULTS: In total, 14,200 children contributed with 16,345 AKI episodes over 15 years. The mean annual AKI rate was 148 (95% CI: 141-155) per 100,000 children. From 2007 to 2021, the annual AKI rate demonstrated minor year-to-year variability without any discernible overall trend. The highest AKI rate was recorded in 2007 at 174 (95% CI: 161-187) per 100,000 children, while the lowest rate occurred in 2012 at 129 (95% CI: 118-140) per 100,000 children. In 2021, the AKI rate was 148 (95% CI: 141-155) per 100,000 children. Characteristics of children with AKI were similar throughout the study period.CONCLUSION: The rate of AKI among Danish children was stable from 2007 to 2021 with little variation in patient characteristics over time. A higher resolution version of the Graphical abstract is available as Supplementary information.",

keywords = "Acute kidney injury, Epidemiology, Pediatric nephrology, Temporal trends, Sepsis/complications, Humans, Risk Factors, Denmark, Retrospective Studies, Acute Kidney Injury/etiology, Child, Cohort Studies",

author = "Sidse H{\o}yer and Uffe Heide-J{\o}rgensen and Jensen, {Simon Kok} and Mette N{\o}rgaard and Cara Slagle and Stuart Goldstein and Christiansen, {Christian Fynbo}",

year = "2024",

month = jun,

doi = "10.1007/s00467-023-06246-9",

language = "English",

volume = "39",

pages = "1917--1925",

journal = "Pediatric Nephrology",

issn = "0931-041X",

publisher = "Springer Science and Business Media Deutschland GmbH",

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T1 - Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark

AU - Høyer, Sidse

AU - Heide-Jørgensen, Uffe

AU - Jensen, Simon Kok

AU - Nørgaard, Mette

AU - Slagle, Cara

AU - Goldstein, Stuart

AU - Christiansen, Christian Fynbo

PY - 2024/6

Y1 - 2024/6

N2 - BACKGROUND: We aimed to examine temporal changes in the annual rate of acute kidney injury (AKI) in Danish children and associated changes in patient characteristics including potential underlying risk factors.METHODS: In this population-based cohort study, we used plasma creatinine measurements from Danish laboratory databases to identify AKI episodes in children aged 0-17 years from 2007 to 2021. For each child, the first AKI episode per calendar year was included. We estimated the annual crude and sex- and age-standardized AKI rate as the number of children with an AKI episode divided by the total number of children as reported by census numbers. Using Danish medical databases, we assessed patient characteristics including potential risk factors for AKI, such as use of nephrotoxic medication, surgery, sepsis, and perinatal factors.RESULTS: In total, 14,200 children contributed with 16,345 AKI episodes over 15 years. The mean annual AKI rate was 148 (95% CI: 141-155) per 100,000 children. From 2007 to 2021, the annual AKI rate demonstrated minor year-to-year variability without any discernible overall trend. The highest AKI rate was recorded in 2007 at 174 (95% CI: 161-187) per 100,000 children, while the lowest rate occurred in 2012 at 129 (95% CI: 118-140) per 100,000 children. In 2021, the AKI rate was 148 (95% CI: 141-155) per 100,000 children. Characteristics of children with AKI were similar throughout the study period.CONCLUSION: The rate of AKI among Danish children was stable from 2007 to 2021 with little variation in patient characteristics over time. A higher resolution version of the Graphical abstract is available as Supplementary information.

AB - BACKGROUND: We aimed to examine temporal changes in the annual rate of acute kidney injury (AKI) in Danish children and associated changes in patient characteristics including potential underlying risk factors.METHODS: In this population-based cohort study, we used plasma creatinine measurements from Danish laboratory databases to identify AKI episodes in children aged 0-17 years from 2007 to 2021. For each child, the first AKI episode per calendar year was included. We estimated the annual crude and sex- and age-standardized AKI rate as the number of children with an AKI episode divided by the total number of children as reported by census numbers. Using Danish medical databases, we assessed patient characteristics including potential risk factors for AKI, such as use of nephrotoxic medication, surgery, sepsis, and perinatal factors.RESULTS: In total, 14,200 children contributed with 16,345 AKI episodes over 15 years. The mean annual AKI rate was 148 (95% CI: 141-155) per 100,000 children. From 2007 to 2021, the annual AKI rate demonstrated minor year-to-year variability without any discernible overall trend. The highest AKI rate was recorded in 2007 at 174 (95% CI: 161-187) per 100,000 children, while the lowest rate occurred in 2012 at 129 (95% CI: 118-140) per 100,000 children. In 2021, the AKI rate was 148 (95% CI: 141-155) per 100,000 children. Characteristics of children with AKI were similar throughout the study period.CONCLUSION: The rate of AKI among Danish children was stable from 2007 to 2021 with little variation in patient characteristics over time. A higher resolution version of the Graphical abstract is available as Supplementary information.

KW - Acute kidney injury

KW - Epidemiology

KW - Pediatric nephrology

KW - Temporal trends

KW - Sepsis/complications

KW - Humans

KW - Risk Factors

KW - Denmark

KW - Retrospective Studies

KW - Acute Kidney Injury/etiology

KW - Child

KW - Cohort Studies

UR - http://www.scopus.com/inward/record.url?scp=85180228995&partnerID=8YFLogxK

U2 - 10.1007/s00467-023-06246-9

DO - 10.1007/s00467-023-06246-9

M3 - Journal article

C2 - 38108933

SN - 0931-041X

VL - 39

SP - 1917

EP - 1925

JO - Pediatric Nephrology

JF - Pediatric Nephrology

IS - 6

ER -

Fifteen-year temporal changes in rates of acute kidney injury among children in Denmark

Abstract

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