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Fibroblast Growth Factor 19 in Gestational Diabetes Mellitus and Fetal Growth

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DOI

  • Meng Nan Yang, Shanghai Jiao Tong University, University of Toronto
  • ,
  • Rong Huang, University of Toronto
  • ,
  • Xin Liu, Shanghai Jiao Tong University
  • ,
  • Ya Jie Xu, Shanghai Jiao Tong University
  • ,
  • Wen Juan Wang, Shanghai Jiao Tong University
  • ,
  • Hua He, Shanghai Jiao Tong University
  • ,
  • Guang Hui Zhang, Shanghai Jiao Tong University
  • ,
  • Tao Zheng, Shanghai Jiao Tong University
  • ,
  • Fang Fang, Ministry of Education-Shanghai Key Laboratory of Children’s Environmental Health, Shanghai Jiao Tong University
  • ,
  • Jian Gao Fan, Shanghai Jiao Tong University
  • ,
  • Fei Li, Shanghai Jiao Tong University
  • ,
  • Jun Zhang, Shanghai Jiao Tong University
  • ,
  • Jiong Li
  • Fengxiu Ouyang, Shanghai Jiao Tong University
  • ,
  • Zhong Cheng Luo, Shanghai Jiao Tong University, University of Toronto
  • ,
  • the Shanghai Birth Cohort

Fibroblast growth factor 19 (FGF19) has been implicated in glucose homeostasis. Gestational diabetes mellitus (GDM) enhances fetal insulin secretion and fetal growth. Girls weigh less and are more insulin resistant than boys at birth. We sought to assess whether FGF19 is associated with GDM and fetal growth and explore potential sex dimorphic associations. This was a nested case-control study in the Shanghai Birth Cohort, including 153 pairs of newborns of GDM versus euglycemic mothers matched by infant’s sex and gestational age at birth. Cord plasma FGF19, insulin, C-peptide, proinsulin, IGF-I and IGF-II concentrations were measured. Cord plasma FGF19 concentrations were similar in GDM versus euglycemic pregnancies (mean ± SD: 43.5 ± 28.2 versus 44.5 ± 30.2 pg/mL, P=0.38). FGF19 was not correlated with IGF-I or IGF-II. FGF19 concentrations were positively correlated with birth weight (r=0.23, P=0.01) and length (r=0.21, P=0.02) z scores, C-peptide (r=0.27, P=0.002) and proinsulin (r=0.27, P=0.002) concentrations in females. Each SD increment in cord plasma FGF19 was associated with a 0.25 (0.07-0.43) increase in birth weight z score in females. In contrast, FGF19 was not correlated with birth weight or length in males. These sex dimorphic associations remained after adjusting for maternal and neonatal characteristics. The study is the first to demonstrate that GDM does not matter for cord blood FGF19 concentrations. The female specific positive correlation between FGF19 and birth weight is suggestive of a sex-dimorphic role of FGF19 in fetal growth. The observations call for more studies to validate the novel findings and elucidate the underlying mechanisms.

OriginalsprogEngelsk
Artikelnummer805722
TidsskriftFrontiers in Endocrinology
Vol/bind12
Antal sider8
ISSN1664-2392
DOI
StatusUdgivet - jan. 2022

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