Contact
Fetal programming and Wilms tumor
Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Standard
Fetal programming and Wilms tumor. / Heck, Julia E; He, Di; Janzen, Carla; Federman, Noah; Olsen, Jorn; Ritz, Beate; Hansen, Johnni.
I: Pediatric Blood & Cancer, Bind 66, Nr. 1, e27461, 01.2019.Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review
Harvard
APA
CBE
MLA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Fetal programming and Wilms tumor
AU - Heck, Julia E
AU - He, Di
AU - Janzen, Carla
AU - Federman, Noah
AU - Olsen, Jorn
AU - Ritz, Beate
AU - Hansen, Johnni
N1 - © 2018 Wiley Periodicals, Inc.
PY - 2019/1
Y1 - 2019/1
N2 - Background The "fetal programming" hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth length, ponderal index, or placenta size, which can shed additional light on growth patterns. Methods Results Cases of Wilms tumor (N = 217) were taken from the Danish Cancer Registry, and controls (N = 4340) were randomly selected from the Population Register and matched to cases by sex and age. Linkage to the Medical Births Registry provided information on gestational factors and fetal growth measurements, while linkage to the Patient Register provided information on maternal and child health conditions. Despite having typically normal to higher birthweights, Wilms tumor cases had smaller placentas (4000 g; OR = 1.57; 95% CI, 1.11-2.22), birth length 55 cm or longer (OR = 1.74; 95% CI, 1.09-2.78), and being large for gestational age (OR = 1.79; 95% CI, 1.08-2.96). Conclusions Our study corroborates earlier studies showing associations with high birthweight and suggests associations between Wilms tumor and decreased placental size and low placenta-to-birthweight ratio.
AB - Background The "fetal programming" hypothesis has been evaluated in many adult diseases including cancer, but not for Wilms tumor. Wilms tumor has been related to high birthweight, but little is known about other growth metrics such as a baby's birth length, ponderal index, or placenta size, which can shed additional light on growth patterns. Methods Results Cases of Wilms tumor (N = 217) were taken from the Danish Cancer Registry, and controls (N = 4340) were randomly selected from the Population Register and matched to cases by sex and age. Linkage to the Medical Births Registry provided information on gestational factors and fetal growth measurements, while linkage to the Patient Register provided information on maternal and child health conditions. Despite having typically normal to higher birthweights, Wilms tumor cases had smaller placentas (4000 g; OR = 1.57; 95% CI, 1.11-2.22), birth length 55 cm or longer (OR = 1.74; 95% CI, 1.09-2.78), and being large for gestational age (OR = 1.79; 95% CI, 1.08-2.96). Conclusions Our study corroborates earlier studies showing associations with high birthweight and suggests associations between Wilms tumor and decreased placental size and low placenta-to-birthweight ratio.
KW - birthweight
KW - body size
KW - fetal development
KW - nephroblastoma
KW - placenta
U2 - 10.1002/pbc.27461
DO - 10.1002/pbc.27461
M3 - Journal article
VL - 66
JO - Pediatric Blood & Cancer
JF - Pediatric Blood & Cancer
SN - 1545-5009
IS - 1
M1 - e27461
ER -