Fetal Heart Defects and Measures of Cerebral Size

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Fetal Heart Defects and Measures of Cerebral Size. / Lauridsen, Mette Høj; Uldbjerg, Niels; Petersen, Olav Bjørn; Vestergaard, Else Marie; Matthiesen, Niels Bjerregaard; Henriksen, Tine Brink; Østergaard, John Rosendahl; Hjortdal, Vibeke Elisabeth.

I: The Journal of Pediatrics, Bind 210, 2019, s. 146-153.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

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@article{018a39a7689b476c8b44f67d99555027,
title = "Fetal Heart Defects and Measures of Cerebral Size",
abstract = "OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95{\%} CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95{\%} CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.",
keywords = "CHD, congenital heart defects, fetal growth, fetal neurodevelopment, follow-up, head circumference, neurodevelopment, pregnancy, BRAIN-DEVELOPMENT, NEURODEVELOPMENTAL OUTCOMES, NEWBORNS, CHILDREN, NATIONWIDE, DISEASE, GROWTH, BIOMETRY, FETUSES, ASSOCIATION",
author = "Lauridsen, {Mette H{\o}j} and Niels Uldbjerg and Petersen, {Olav Bj{\o}rn} and Vestergaard, {Else Marie} and Matthiesen, {Niels Bjerregaard} and Henriksen, {Tine Brink} and {\O}stergaard, {John Rosendahl} and Hjortdal, {Vibeke Elisabeth}",
note = "Copyright {\circledC} 2019 Elsevier Inc. All rights reserved.",
year = "2019",
doi = "10.1016/j.jpeds.2019.02.042",
language = "English",
volume = "210",
pages = "146--153",
journal = "Journal of Pediatrics",
issn = "0022-3476",
publisher = "Mosby, Inc",

}

RIS

TY - JOUR

T1 - Fetal Heart Defects and Measures of Cerebral Size

AU - Lauridsen, Mette Høj

AU - Uldbjerg, Niels

AU - Petersen, Olav Bjørn

AU - Vestergaard, Else Marie

AU - Matthiesen, Niels Bjerregaard

AU - Henriksen, Tine Brink

AU - Østergaard, John Rosendahl

AU - Hjortdal, Vibeke Elisabeth

N1 - Copyright © 2019 Elsevier Inc. All rights reserved.

PY - 2019

Y1 - 2019

N2 - OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.

AB - OBJECTIVES: To estimate the association between fetal congenital heart defects (CHDs) and measures of brain size throughout pregnancy, from the end of the first trimester to birth.STUDY DESIGN: The cohort consisted of all fetuses scanned in Western Denmark in 2012 and 2013. Anthropometric measures in fetuses with isolated CHDs diagnosed within 12 months after birth were compared with those in the fetuses without CHDs. Z-scores standardized to gestational age were calculated for first trimester biparietal diameter, second trimester head circumference, fetal weight, birthweight, head circumference, and placental weight.RESULTS: We obtained data from 63 349 pregnancies and identified 295 fetuses with isolated CHDs (major n = 145; minor n = 150). The first trimester mean biparietal diameter Z-scores were not different between those with and those without CHDs. The head circumference mean Z-score difference was -0.13 (95% CI, -0.24 to -0.01; P = .03) in the second trimester and -0.22 (95% CI, -0.35 to -0.09; P < .001) at birth. Fetuses with univentricular physiology or tetralogy of Fallot showed the most pronounced compromise in cerebral size.CONCLUSIONS: Our results suggest that the brain alterations inducing an increased risk of impaired neurodevelopment in children with CHDs begin during pregnancy. Although fetuses with univentricular physiology or tetralogy of Fallot exhibited the most pronounced compromise in cerebral size, we recommend neurodevelopmental follow-up for all children with CHDs.

KW - CHD

KW - congenital heart defects

KW - fetal growth

KW - fetal neurodevelopment

KW - follow-up

KW - head circumference

KW - neurodevelopment

KW - pregnancy

KW - BRAIN-DEVELOPMENT

KW - NEURODEVELOPMENTAL OUTCOMES

KW - NEWBORNS

KW - CHILDREN

KW - NATIONWIDE

KW - DISEASE

KW - GROWTH

KW - BIOMETRY

KW - FETUSES

KW - ASSOCIATION

UR - http://www.scopus.com/inward/record.url?scp=85063813031&partnerID=8YFLogxK

U2 - 10.1016/j.jpeds.2019.02.042

DO - 10.1016/j.jpeds.2019.02.042

M3 - Journal article

VL - 210

SP - 146

EP - 153

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -