TY - JOUR
T1 - Fertility treatment and childhood type 1 diabetes mellitus
T2 - a nationwide cohort study of 565,116 live births
AU - Kettner, Laura Ozer
AU - Matthiesen, Niels Bjerregaard
AU - Ramlau-Hansen, Cecilia Høst
AU - Kesmodel, Ulrik Schiøler
AU - Bay, Bjørn
AU - Henriksen, Tine Brink
N1 - Copyright © 2016 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved.
PY - 2016/12
Y1 - 2016/12
N2 - OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.DESIGN: Nationwide birth cohort study.SETTING: Not applicable.PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.INTERVENTION(S): Not applicable.MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.
AB - OBJECTIVE: To investigate the association between specific types of fertility treatment and childhood type 1 diabetes mellitus.DESIGN: Nationwide birth cohort study.SETTING: Not applicable.PATIENT(S): All pregnancies resulting in a live-born singleton child in Denmark from 1995 to 2003.INTERVENTION(S): Not applicable.MAIN OUTCOME MEASURE(S): Childhood type 1 diabetes mellitus identified from redeemed prescriptions for insulin until 2013.RESULT(S): The study included 565,116 singleton pregnancies. A total of 14,985 children were conceived by ovulation induction or intrauterine insemination, and 8,490 children were conceived by in vitro fertilization or intracytoplasmic sperm injection. During the follow-up period, 2,011 (0.4%) children developed type 1 diabetes mellitus. The primary analyses showed no association between fertility treatment and childhood type 1 diabetes mellitus. In secondary analyses, ovulation induction or intrauterine insemination with follicle-stimulating hormone was associated with an increased risk of type 1 diabetes mellitus (hazard ratio 3.22; 95% confidence interval 1.20 to 8.64). No clear associations were seen with other types of fertility treatment or with specific treatment indications.CONCLUSION(S): No association between fertility treatment and childhood type 1 diabetes mellitus was found. Ovulation induction or intrauterine insemination with follicle-stimulating hormone may be associated with an increased risk of childhood type 1 diabetes mellitus. However, this finding may be due to chance or to confounding by indication and thus requires further investigation.
KW - Assisted reproductive technology
KW - intracytoplasmic sperm injection
KW - intrauterine insemination
KW - in vitro fertilization
KW - ovulation induction
KW - type 1 diabetes mellitus
UR - http://www.scopus.com/inward/record.url?scp=84999025980&partnerID=8YFLogxK
U2 - 10.1016/j.fertnstert.2016.09.009
DO - 10.1016/j.fertnstert.2016.09.009
M3 - Journal article
C2 - 27773424
SN - 0015-0282
VL - 106
SP - 1751
EP - 1756
JO - Fertility and Sterility
JF - Fertility and Sterility
IS - 7
ER -