Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort

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Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset : data from the prospective Nordic JIA cohort. / Arnstad, Ellen Dalen; Glerup, Mia; Rypdal, Veronika; Peltoniemi, Suvi; Fasth, Anders; Nielsen, Susan; Zak, Marek; Aalto, Kristiina; Berntson, Lillemor; Nordal, Ellen; Herlin, Troels; Romundstad, Pål Richard; Rygg, Marite; on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR).

I: Pediatric Rheumatology , Bind 19, Nr. 1, 33, 2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Arnstad, ED, Glerup, M, Rypdal, V, Peltoniemi, S, Fasth, A, Nielsen, S, Zak, M, Aalto, K, Berntson, L, Nordal, E, Herlin, T, Romundstad, PR, Rygg, M & on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR) 2021, 'Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort', Pediatric Rheumatology , bind 19, nr. 1, 33. https://doi.org/10.1186/s12969-021-00499-0

APA

Arnstad, E. D., Glerup, M., Rypdal, V., Peltoniemi, S., Fasth, A., Nielsen, S., Zak, M., Aalto, K., Berntson, L., Nordal, E., Herlin, T., Romundstad, P. R., Rygg, M., & on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR) (2021). Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort. Pediatric Rheumatology , 19(1), [33]. https://doi.org/10.1186/s12969-021-00499-0

CBE

Arnstad ED, Glerup M, Rypdal V, Peltoniemi S, Fasth A, Nielsen S, Zak M, Aalto K, Berntson L, Nordal E, Herlin T, Romundstad PR, Rygg M, on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR). 2021. Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort. Pediatric Rheumatology . 19(1):Article 33. https://doi.org/10.1186/s12969-021-00499-0

MLA

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Author

Arnstad, Ellen Dalen ; Glerup, Mia ; Rypdal, Veronika ; Peltoniemi, Suvi ; Fasth, Anders ; Nielsen, Susan ; Zak, Marek ; Aalto, Kristiina ; Berntson, Lillemor ; Nordal, Ellen ; Herlin, Troels ; Romundstad, Pål Richard ; Rygg, Marite ; on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR). / Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset : data from the prospective Nordic JIA cohort. I: Pediatric Rheumatology . 2021 ; Bind 19, Nr. 1.

Bibtex

@article{0ff2a28fe1334246a1d08afe22a8fbd1,
title = "Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset: data from the prospective Nordic JIA cohort",
abstract = "Background: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1–7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used. Results: Among 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease-modifying anti-rheumatic drugs (DMARDs)/biologics/systemic steroids. In contrast, participants without these challenges, had fatigue scores similar to controls. Active disease assessed at all three time points (baseline, 8-year and 18-year follow-up) was associated with higher mean fatigue score and higher percentage of severe fatigue compared to disease courses characterized by periods of inactive disease. Predictors of fatigue at the 18-year follow-up were female sex and diagnostic delay of ≥6 months at baseline, and also pain, self-reported poor health, active disease, and previous/ongoing use of DMARDs/biologics at 8 years. Conclusions: Fatigue is a prominent symptom in young adults with JIA, with higher fatigue burden among participants with poor sleep, pain, self-reported health problems, active disease, or use of DMARDs/biologics. Participants without these challenges have results similar to controls. Patient- and physician-reported variables at baseline and during disease course predicted fatigue at 18-year follow-up.",
keywords = "Fatigue, Health-related quality of life (HRQoL), Juvenile idiopathic arthritis (JIA), Long-term outcomes, Patient-reported outcomes, Young adults",
author = "Arnstad, {Ellen Dalen} and Mia Glerup and Veronika Rypdal and Suvi Peltoniemi and Anders Fasth and Susan Nielsen and Marek Zak and Kristiina Aalto and Lillemor Berntson and Ellen Nordal and Troels Herlin and Romundstad, {P{\aa}l Richard} and Marite Rygg and {on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR)}",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2021",
doi = "10.1186/s12969-021-00499-0",
language = "English",
volume = "19",
journal = "Pediatric Rheumatology ",
issn = "1546-0096",
publisher = "BMC",
number = "1",

}

RIS

TY - JOUR

T1 - Fatigue in young adults with juvenile idiopathic arthritis 18 years after disease onset

T2 - data from the prospective Nordic JIA cohort

AU - Arnstad, Ellen Dalen

AU - Glerup, Mia

AU - Rypdal, Veronika

AU - Peltoniemi, Suvi

AU - Fasth, Anders

AU - Nielsen, Susan

AU - Zak, Marek

AU - Aalto, Kristiina

AU - Berntson, Lillemor

AU - Nordal, Ellen

AU - Herlin, Troels

AU - Romundstad, Pål Richard

AU - Rygg, Marite

AU - on behalf of the Nordic Study Group of Pediatric Rheumatology (NoSPeR)

N1 - Publisher Copyright: © 2021, The Author(s). Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021

Y1 - 2021

N2 - Background: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1–7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used. Results: Among 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease-modifying anti-rheumatic drugs (DMARDs)/biologics/systemic steroids. In contrast, participants without these challenges, had fatigue scores similar to controls. Active disease assessed at all three time points (baseline, 8-year and 18-year follow-up) was associated with higher mean fatigue score and higher percentage of severe fatigue compared to disease courses characterized by periods of inactive disease. Predictors of fatigue at the 18-year follow-up were female sex and diagnostic delay of ≥6 months at baseline, and also pain, self-reported poor health, active disease, and previous/ongoing use of DMARDs/biologics at 8 years. Conclusions: Fatigue is a prominent symptom in young adults with JIA, with higher fatigue burden among participants with poor sleep, pain, self-reported health problems, active disease, or use of DMARDs/biologics. Participants without these challenges have results similar to controls. Patient- and physician-reported variables at baseline and during disease course predicted fatigue at 18-year follow-up.

AB - Background: To study fatigue in young adults with juvenile idiopathic arthritis (JIA) 18 years after disease onset, and to compare with controls. Methods: Consecutive children with onset of JIA between 1997 and 2000, from geographically defined areas of Norway, Sweden, Denmark and Finland were followed for 18 years in a close to population-based prospective cohort study. Clinical features, demographic and patient-reported data were collected. Inclusion criteria in the present study were a baseline visit 6 months after disease onset, followed by an 18-year follow-up with available self-reported fatigue score (Fatigue Severity Scale (FSS), 1–7). Severe fatigue was defined as FSS ≥4. For comparison, Norwegian age and sex matched controls were used. Results: Among 377 young adults with JIA, 26% reported severe fatigue, compared to 12% among controls. We found higher burden of fatigue among participants with sleep problems, pain, poor health, reduced participation in school/work, physical disability, active disease, or use of disease-modifying anti-rheumatic drugs (DMARDs)/biologics/systemic steroids. In contrast, participants without these challenges, had fatigue scores similar to controls. Active disease assessed at all three time points (baseline, 8-year and 18-year follow-up) was associated with higher mean fatigue score and higher percentage of severe fatigue compared to disease courses characterized by periods of inactive disease. Predictors of fatigue at the 18-year follow-up were female sex and diagnostic delay of ≥6 months at baseline, and also pain, self-reported poor health, active disease, and previous/ongoing use of DMARDs/biologics at 8 years. Conclusions: Fatigue is a prominent symptom in young adults with JIA, with higher fatigue burden among participants with poor sleep, pain, self-reported health problems, active disease, or use of DMARDs/biologics. Participants without these challenges have results similar to controls. Patient- and physician-reported variables at baseline and during disease course predicted fatigue at 18-year follow-up.

KW - Fatigue

KW - Health-related quality of life (HRQoL)

KW - Juvenile idiopathic arthritis (JIA)

KW - Long-term outcomes

KW - Patient-reported outcomes

KW - Young adults

UR - http://www.scopus.com/inward/record.url?scp=85102818976&partnerID=8YFLogxK

U2 - 10.1186/s12969-021-00499-0

DO - 10.1186/s12969-021-00499-0

M3 - Journal article

C2 - 33736650

AN - SCOPUS:85102818976

VL - 19

JO - Pediatric Rheumatology

JF - Pediatric Rheumatology

SN - 1546-0096

IS - 1

M1 - 33

ER -