Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Standard

Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. / Knudsen, Julie Kristine; Michaelsen, Thomas Yssing; Bundgaard-Nielsen, Caspar; Nielsen, René Ernst; Hjerrild, Simon; Leutscher, Peter; Wegener, Gregers; Sørensen, Suzette.

I: Scientific Reports, Bind 11, Nr. 1, 21869, 11.2021.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Knudsen, JK, Michaelsen, TY, Bundgaard-Nielsen, C, Nielsen, RE, Hjerrild, S, Leutscher, P, Wegener, G & Sørensen, S 2021, 'Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour', Scientific Reports, bind 11, nr. 1, 21869. https://doi.org/10.1038/s41598-021-01248-9

APA

Knudsen, J. K., Michaelsen, T. Y., Bundgaard-Nielsen, C., Nielsen, R. E., Hjerrild, S., Leutscher, P., Wegener, G., & Sørensen, S. (2021). Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. Scientific Reports, 11(1), [21869]. https://doi.org/10.1038/s41598-021-01248-9

CBE

Knudsen JK, Michaelsen TY, Bundgaard-Nielsen C, Nielsen RE, Hjerrild S, Leutscher P, Wegener G, Sørensen S. 2021. Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. Scientific Reports. 11(1):Article 21869. https://doi.org/10.1038/s41598-021-01248-9

MLA

Vancouver

Knudsen JK, Michaelsen TY, Bundgaard-Nielsen C, Nielsen RE, Hjerrild S, Leutscher P o.a. Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. Scientific Reports. 2021 nov.;11(1). 21869. https://doi.org/10.1038/s41598-021-01248-9

Author

Knudsen, Julie Kristine ; Michaelsen, Thomas Yssing ; Bundgaard-Nielsen, Caspar ; Nielsen, René Ernst ; Hjerrild, Simon ; Leutscher, Peter ; Wegener, Gregers ; Sørensen, Suzette. / Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour. I: Scientific Reports. 2021 ; Bind 11, Nr. 1.

Bibtex

@article{617ee57cd19d467ab02f8f2ce9827c7a,
title = "Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour",
abstract = "Differences in gut microbiota composition have been observed in patients with major depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal microbiota transplantation (FMT) from patients with MDD into rats could induce a depressive-like phenotype. We performed FMT from patients with MDD (FMT-MDD) and healthy individuals (FMT-Healthy) into male Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats and assessed depressive-like behaviour. No behavioural differences were observed in the FSL rats. In FRL rats, the FMT-Healthy group displayed significantly less depressive-like behaviour than the FMT-MDD group. However, there was no difference in behaviour between FMT-MDD FRL rats and negative controls, indicating that FMT-Healthy FRL rats received beneficial bacteria. We additionally found different taxa between the FMT-MDD and the FMT-Healthy FRL rats, which could be traced to the donors. Four taxa, three belonging to the family Ruminococcaceae and the genus Lachnospira, were significantly elevated in relative abundance in FMT-MDD rats, while the genus Coprococcus was depleted. In this study, the FMT-MDD group was different from the FMT-Healthy group based on behaviour and intestinal taxa.",
author = "Knudsen, {Julie Kristine} and Michaelsen, {Thomas Yssing} and Caspar Bundgaard-Nielsen and Nielsen, {Ren{\'e} Ernst} and Simon Hjerrild and Peter Leutscher and Gregers Wegener and Suzette S{\o}rensen",
year = "2021",
month = nov,
doi = "10.1038/s41598-021-01248-9",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Faecal microbiota transplantation from patients with depression or healthy individuals into rats modulates mood-related behaviour

AU - Knudsen, Julie Kristine

AU - Michaelsen, Thomas Yssing

AU - Bundgaard-Nielsen, Caspar

AU - Nielsen, René Ernst

AU - Hjerrild, Simon

AU - Leutscher, Peter

AU - Wegener, Gregers

AU - Sørensen, Suzette

PY - 2021/11

Y1 - 2021/11

N2 - Differences in gut microbiota composition have been observed in patients with major depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal microbiota transplantation (FMT) from patients with MDD into rats could induce a depressive-like phenotype. We performed FMT from patients with MDD (FMT-MDD) and healthy individuals (FMT-Healthy) into male Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats and assessed depressive-like behaviour. No behavioural differences were observed in the FSL rats. In FRL rats, the FMT-Healthy group displayed significantly less depressive-like behaviour than the FMT-MDD group. However, there was no difference in behaviour between FMT-MDD FRL rats and negative controls, indicating that FMT-Healthy FRL rats received beneficial bacteria. We additionally found different taxa between the FMT-MDD and the FMT-Healthy FRL rats, which could be traced to the donors. Four taxa, three belonging to the family Ruminococcaceae and the genus Lachnospira, were significantly elevated in relative abundance in FMT-MDD rats, while the genus Coprococcus was depleted. In this study, the FMT-MDD group was different from the FMT-Healthy group based on behaviour and intestinal taxa.

AB - Differences in gut microbiota composition have been observed in patients with major depressive disorder (MDD) compared to healthy individuals. Here, we investigated if faecal microbiota transplantation (FMT) from patients with MDD into rats could induce a depressive-like phenotype. We performed FMT from patients with MDD (FMT-MDD) and healthy individuals (FMT-Healthy) into male Flinders Sensitive Line (FSL) and Flinders Resistant Line (FRL) rats and assessed depressive-like behaviour. No behavioural differences were observed in the FSL rats. In FRL rats, the FMT-Healthy group displayed significantly less depressive-like behaviour than the FMT-MDD group. However, there was no difference in behaviour between FMT-MDD FRL rats and negative controls, indicating that FMT-Healthy FRL rats received beneficial bacteria. We additionally found different taxa between the FMT-MDD and the FMT-Healthy FRL rats, which could be traced to the donors. Four taxa, three belonging to the family Ruminococcaceae and the genus Lachnospira, were significantly elevated in relative abundance in FMT-MDD rats, while the genus Coprococcus was depleted. In this study, the FMT-MDD group was different from the FMT-Healthy group based on behaviour and intestinal taxa.

U2 - 10.1038/s41598-021-01248-9

DO - 10.1038/s41598-021-01248-9

M3 - Journal article

C2 - 34750433

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 21869

ER -