Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

Martin Iain Bahl; Simon Mark Dahl Jørgensen; Alberte Hjortgård Skriver; Nanna Alsig Larsen; Mikala Wang; Tine Rask Licht; Jens Frederik Dahlerup; Christian Lodberg Hvas

doi:10.1080/00365521.2020.1753806

Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

Martin Iain Bahl, Simon Mark Dahl Jørgensen, Alberte Hjortgård Skriver, Nanna Alsig Larsen, Mikala Wang, Tine Rask Licht, Jens Frederik Dahlerup, Christian Lodberg Hvas

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

5 Citationer (Scopus)

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Abstract

Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.

Originalsprog	Engelsk
Tidsskrift	Scandinavian Journal of Gastroenterology
Vol/bind	55
Nummer	5
Sider (fra-til)	626-630
Antal sider	5
ISSN	0036-5521
DOI	https://doi.org/10.1080/00365521.2020.1753806
Status	Udgivet - maj 2020

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10.1080/00365521.2020.1753806Licens: CC BY-NC-ND

Faecal microbiota transplantation for eradication of co infection with Clostridioides difficile and extensively drug resistant KPC producingForlagets udgivne version, 1,33 MBLicens: CC BY-NC-ND

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Bahl, M. I., Jørgensen, S. M. D., Skriver, A. H., Larsen, N. A., Wang, M., Licht, T. R., Dahlerup, J. F., & Hvas, C. L. (2020). Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae. Scandinavian Journal of Gastroenterology, 55(5), 626-630. https://doi.org/10.1080/00365521.2020.1753806

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title = "Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae",

abstract = "Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.",

keywords = "Clostridioides difficile, Faecal microbiota transplantation, Klebsiella pneumoniae, drug resistance",

author = "Bahl, {Martin Iain} and J{\o}rgensen, {Simon Mark Dahl} and Skriver, {Alberte Hjortg{\aa}rd} and Larsen, {Nanna Alsig} and Mikala Wang and Licht, {Tine Rask} and Dahlerup, {Jens Frederik} and Hvas, {Christian Lodberg}",

year = "2020",

month = may,

doi = "10.1080/00365521.2020.1753806",

language = "English",

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Bahl, MI, Jørgensen, SMD, Skriver, AH, Larsen, NA, Wang, M, Licht, TR, Dahlerup, JF & Hvas, CL 2020, 'Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae', Scandinavian Journal of Gastroenterology, bind 55, nr. 5, s. 626-630. https://doi.org/10.1080/00365521.2020.1753806

Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae. / Bahl, Martin Iain; Jørgensen, Simon Mark Dahl; Skriver, Alberte Hjortgård et al.
I: Scandinavian Journal of Gastroenterology, Bind 55, Nr. 5, 05.2020, s. 626-630.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

AU - Bahl, Martin Iain

AU - Jørgensen, Simon Mark Dahl

AU - Skriver, Alberte Hjortgård

AU - Larsen, Nanna Alsig

AU - Wang, Mikala

AU - Licht, Tine Rask

AU - Dahlerup, Jens Frederik

AU - Hvas, Christian Lodberg

PY - 2020/5

Y1 - 2020/5

N2 - Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.

AB - Clostridioides difficile infection may be complicated by co-infection with other pathogens. We here describe the successful use of faecal microbiota transplantation to eradicate concomitant C. difficile and extensively drug-resistant (XDR) KPC-producing Klebsiella pneumoniae. Donor microbiota efficiently engrafted in the patient, and a donor-like microbial assemblage persisted in the patient during six months follow-up. The report explores the potential for the donor microbiota to eradicate and replace multi-resistant microorganisms.

KW - Clostridioides difficile

KW - Faecal microbiota transplantation

KW - Klebsiella pneumoniae

KW - drug resistance

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U2 - 10.1080/00365521.2020.1753806

DO - 10.1080/00365521.2020.1753806

M3 - Journal article

C2 - 32324085

SN - 0036-5521

VL - 55

SP - 626

EP - 630

JO - Scandinavian Journal of Gastroenterology

JF - Scandinavian Journal of Gastroenterology

IS - 5

ER -

Faecal microbiota transplantation for eradication of co-infection with Clostridioides difficile and extensively drug-resistant KPC-producing Klebsiella pneumoniae

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