Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations

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Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations. / Chaiklieng, Sunisa; Suggaravetsiri, Pornnapa; Kaminski, Norbert; Autrup, Herman.

I: International Journal of Environmental Research and Public Health, Bind 16, Nr. 21, 4209, 01.11.2019.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisTidsskriftartikelForskningpeer review

Harvard

Chaiklieng, S, Suggaravetsiri, P, Kaminski, N & Autrup, H 2019, 'Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations', International Journal of Environmental Research and Public Health, bind 16, nr. 21, 4209. https://doi.org/10.3390/ijerph16214209

APA

Chaiklieng, S., Suggaravetsiri, P., Kaminski, N., & Autrup, H. (2019). Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations. International Journal of Environmental Research and Public Health, 16(21), [4209]. https://doi.org/10.3390/ijerph16214209

CBE

Chaiklieng S, Suggaravetsiri P, Kaminski N, Autrup H. 2019. Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations. International Journal of Environmental Research and Public Health. 16(21):Article 4209. https://doi.org/10.3390/ijerph16214209

MLA

Chaiklieng, Sunisa o.a.. "Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations". International Journal of Environmental Research and Public Health. 2019. 16(21). https://doi.org/10.3390/ijerph16214209

Vancouver

Chaiklieng S, Suggaravetsiri P, Kaminski N, Autrup H. Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations. International Journal of Environmental Research and Public Health. 2019 nov 1;16(21). 4209. https://doi.org/10.3390/ijerph16214209

Author

Chaiklieng, Sunisa ; Suggaravetsiri, Pornnapa ; Kaminski, Norbert ; Autrup, Herman. / Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations. I: International Journal of Environmental Research and Public Health. 2019 ; Bind 16, Nr. 21.

Bibtex

@article{294632036c4547688b77587cbeb114fe,
title = "Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations",
abstract = "Trans, trans-muconic acid (tt-MA) is a metabolite that is widely used as a biomarker to identify low exposure to benzene, a human carcinogen. This study aimed to investigate occupational factors related to the urinary tt-MA detection of benzene exposed workers in gasoline stations. Spot urine samples were collected and analyzed for tt-MA using a high performance liquid chromatography. Additional data were collected via subject interviews using a structured questionnaire. The personal benzene concentration was measured and analyzed by gas chromatography with a flame ionization detector. Results showed that, among the 170 workers, tt-MA was detected in 24.7% of workers and the concentration ranged from 23.0 to 1127.8 µg/g creatinine. Over 25% of those detections possessing tt-MA exceeding the recommended 500 µg/g creatinine was safe. A multiple logistic regression analysis identified that factors significantly associated with the detectable tt-MA were having no other part-time jobs (ORadj = 4.2), personal benzene concentrations of 0.05 ppm or higher (ORadj = 10.3), close to fuel nozzle during refuelling (ORadj = 93.7), and no job training (ORadj = 2.74). Safety training is recommended for those tt-MA detected workers or under a reference benzene concentration of 0.05 ppm or higher. The proposed reference of occupational action level to benzene exposure is 0.05 ppm and compliance could be assessed tt-MA for biomonitoring of those benzene exposed workers.",
keywords = "Benzene, Biomarker, Exposure assessment, Risk",
author = "Sunisa Chaiklieng and Pornnapa Suggaravetsiri and Norbert Kaminski and Herman Autrup",
year = "2019",
month = nov,
day = "1",
doi = "10.3390/ijerph16214209",
language = "English",
volume = "16",
journal = "International Journal of Environmental Research and Public Health",
issn = "1661-7827",
publisher = "MDPI AG",
number = "21",

}

RIS

TY - JOUR

T1 - Factors affecting urinary tt-muconic acid detection among benzene exposed workers at gasoline stations

AU - Chaiklieng, Sunisa

AU - Suggaravetsiri, Pornnapa

AU - Kaminski, Norbert

AU - Autrup, Herman

PY - 2019/11/1

Y1 - 2019/11/1

N2 - Trans, trans-muconic acid (tt-MA) is a metabolite that is widely used as a biomarker to identify low exposure to benzene, a human carcinogen. This study aimed to investigate occupational factors related to the urinary tt-MA detection of benzene exposed workers in gasoline stations. Spot urine samples were collected and analyzed for tt-MA using a high performance liquid chromatography. Additional data were collected via subject interviews using a structured questionnaire. The personal benzene concentration was measured and analyzed by gas chromatography with a flame ionization detector. Results showed that, among the 170 workers, tt-MA was detected in 24.7% of workers and the concentration ranged from 23.0 to 1127.8 µg/g creatinine. Over 25% of those detections possessing tt-MA exceeding the recommended 500 µg/g creatinine was safe. A multiple logistic regression analysis identified that factors significantly associated with the detectable tt-MA were having no other part-time jobs (ORadj = 4.2), personal benzene concentrations of 0.05 ppm or higher (ORadj = 10.3), close to fuel nozzle during refuelling (ORadj = 93.7), and no job training (ORadj = 2.74). Safety training is recommended for those tt-MA detected workers or under a reference benzene concentration of 0.05 ppm or higher. The proposed reference of occupational action level to benzene exposure is 0.05 ppm and compliance could be assessed tt-MA for biomonitoring of those benzene exposed workers.

AB - Trans, trans-muconic acid (tt-MA) is a metabolite that is widely used as a biomarker to identify low exposure to benzene, a human carcinogen. This study aimed to investigate occupational factors related to the urinary tt-MA detection of benzene exposed workers in gasoline stations. Spot urine samples were collected and analyzed for tt-MA using a high performance liquid chromatography. Additional data were collected via subject interviews using a structured questionnaire. The personal benzene concentration was measured and analyzed by gas chromatography with a flame ionization detector. Results showed that, among the 170 workers, tt-MA was detected in 24.7% of workers and the concentration ranged from 23.0 to 1127.8 µg/g creatinine. Over 25% of those detections possessing tt-MA exceeding the recommended 500 µg/g creatinine was safe. A multiple logistic regression analysis identified that factors significantly associated with the detectable tt-MA were having no other part-time jobs (ORadj = 4.2), personal benzene concentrations of 0.05 ppm or higher (ORadj = 10.3), close to fuel nozzle during refuelling (ORadj = 93.7), and no job training (ORadj = 2.74). Safety training is recommended for those tt-MA detected workers or under a reference benzene concentration of 0.05 ppm or higher. The proposed reference of occupational action level to benzene exposure is 0.05 ppm and compliance could be assessed tt-MA for biomonitoring of those benzene exposed workers.

KW - Benzene

KW - Biomarker

KW - Exposure assessment

KW - Risk

UR - http://www.scopus.com/inward/record.url?scp=85074342141&partnerID=8YFLogxK

U2 - 10.3390/ijerph16214209

DO - 10.3390/ijerph16214209

M3 - Journal article

C2 - 31671611

AN - SCOPUS:85074342141

VL - 16

JO - International Journal of Environmental Research and Public Health

JF - International Journal of Environmental Research and Public Health

SN - 1661-7827

IS - 21

M1 - 4209

ER -