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Extracellular Vesicles in Acute Stroke Diagnostics

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Extracellular Vesicles in Acute Stroke Diagnostics. / Stenz, Katrine Tang; Just, Jesper; Blauenfeldt, Rolf Ankerlund; Drasbek, Kim Ryun.

I: Biomedicines, Bind 8, Nr. 8, 248, 2020.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

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@article{2f7548d9c2c64fc5afb948d19c5ddd27,
title = "Extracellular Vesicles in Acute Stroke Diagnostics",
abstract = "There is a large unmet need for fast and reliable diagnostics in several diseases. One such disease is stroke, where the efficacy of modern reperfusion therapies is highly time-dependent. Diagnosis of stroke and treatment initiation should be performed as soon as possible, and preferably before arrival at the stroke center. In recent years, several potential blood biomarkers for stroke have been evaluated, but without success. In this review, we will go into detail on the possibility of utilizing extracellular vesicles (EVs) released into the blood as novel biomarkers for stroke diagnostics. EVs are known to reflect the immediate state of the secreting cells and to be able to cross the blood–brain barrier, thus making them attractive as diagnostic biomarkers of brain diseases. Indeed, several studies have reported EV markers that enable differentiation between stroke patients and controls and, to a lesser extent, the ability to correctly classify the different stroke types. Most of the studies rely on the use of sophisticated and time-consuming methods to quantify specific subpopulations of the nanosized EVs. As these methods cannot be easily implemented in a rapid point of care (POC) test, technical developments followed by prospective clinical studies are needed.",
author = "Stenz, {Katrine Tang} and Jesper Just and Blauenfeldt, {Rolf Ankerlund} and Drasbek, {Kim Ryun}",
year = "2020",
doi = "10.3390/biomedicines8080248",
language = "English",
volume = "8",
journal = "Biomedicines",
issn = "2227-9059",
publisher = "MDPI",
number = "8",

}

RIS

TY - JOUR

T1 - Extracellular Vesicles in Acute Stroke Diagnostics

AU - Stenz, Katrine Tang

AU - Just, Jesper

AU - Blauenfeldt, Rolf Ankerlund

AU - Drasbek, Kim Ryun

PY - 2020

Y1 - 2020

N2 - There is a large unmet need for fast and reliable diagnostics in several diseases. One such disease is stroke, where the efficacy of modern reperfusion therapies is highly time-dependent. Diagnosis of stroke and treatment initiation should be performed as soon as possible, and preferably before arrival at the stroke center. In recent years, several potential blood biomarkers for stroke have been evaluated, but without success. In this review, we will go into detail on the possibility of utilizing extracellular vesicles (EVs) released into the blood as novel biomarkers for stroke diagnostics. EVs are known to reflect the immediate state of the secreting cells and to be able to cross the blood–brain barrier, thus making them attractive as diagnostic biomarkers of brain diseases. Indeed, several studies have reported EV markers that enable differentiation between stroke patients and controls and, to a lesser extent, the ability to correctly classify the different stroke types. Most of the studies rely on the use of sophisticated and time-consuming methods to quantify specific subpopulations of the nanosized EVs. As these methods cannot be easily implemented in a rapid point of care (POC) test, technical developments followed by prospective clinical studies are needed.

AB - There is a large unmet need for fast and reliable diagnostics in several diseases. One such disease is stroke, where the efficacy of modern reperfusion therapies is highly time-dependent. Diagnosis of stroke and treatment initiation should be performed as soon as possible, and preferably before arrival at the stroke center. In recent years, several potential blood biomarkers for stroke have been evaluated, but without success. In this review, we will go into detail on the possibility of utilizing extracellular vesicles (EVs) released into the blood as novel biomarkers for stroke diagnostics. EVs are known to reflect the immediate state of the secreting cells and to be able to cross the blood–brain barrier, thus making them attractive as diagnostic biomarkers of brain diseases. Indeed, several studies have reported EV markers that enable differentiation between stroke patients and controls and, to a lesser extent, the ability to correctly classify the different stroke types. Most of the studies rely on the use of sophisticated and time-consuming methods to quantify specific subpopulations of the nanosized EVs. As these methods cannot be easily implemented in a rapid point of care (POC) test, technical developments followed by prospective clinical studies are needed.

U2 - 10.3390/biomedicines8080248

DO - 10.3390/biomedicines8080248

M3 - Review

C2 - 32731351

VL - 8

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 8

M1 - 248

ER -