Extracellular superoxide dismutase (SOD3): an antioxidant or prooxidant in the extracellular space?

TY - CHAP

T1 - Extracellular superoxide dismutase (SOD3)

T2 - an antioxidant or prooxidant in the extracellular space?

AU - Zachariae, Elias Didrik Francis M

AU - Hu, Lili

AU - Petersen, Steen Vang

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Superoxide dismutase 3 (SOD3 or EC-SOD) is the only scavenger of superoxide in the extracellular space allowing for the catalyzed dismutation of the superoxide radical into hydrogen peroxide. The activity and distribution of the enzyme are regulated at several levels, suggesting the need for balanced activity in the extracellular space. The protein acts as an antioxidant by inhibiting reactions fueled by superoxide, including the reaction with nitric oxide, which generates peroxynitrite. However, the enzyme can also be categorized as a prooxidant providing hydrogen peroxide, which is known to control diverse redox-regulated processes by the oxidation of specific target proteins. The dual role of SOD3 as an antioxidant or prooxidant is central to fine-tuning the redox tone in the extracellular environment and warrants further investigations to fully understand the role of this protein in health and disease.

AB - Superoxide dismutase 3 (SOD3 or EC-SOD) is the only scavenger of superoxide in the extracellular space allowing for the catalyzed dismutation of the superoxide radical into hydrogen peroxide. The activity and distribution of the enzyme are regulated at several levels, suggesting the need for balanced activity in the extracellular space. The protein acts as an antioxidant by inhibiting reactions fueled by superoxide, including the reaction with nitric oxide, which generates peroxynitrite. However, the enzyme can also be categorized as a prooxidant providing hydrogen peroxide, which is known to control diverse redox-regulated processes by the oxidation of specific target proteins. The dual role of SOD3 as an antioxidant or prooxidant is central to fine-tuning the redox tone in the extracellular environment and warrants further investigations to fully understand the role of this protein in health and disease.

KW - Extracellular

KW - Hydrogen peroxide

KW - Hypertension

KW - Inflammation

KW - Redox signaling

KW - Superoxide dismutase

KW - Vascular disease

UR - https://www.scopus.com/pages/publications/85093493032

M3 - Book chapter

SN - 9780128186060

SP - 183

EP - 216

BT - Oxidative stress

A2 - Sies, Helmut

PB - Academic Press

CY - London

ER -