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Extensive Literature Search on the “Effects of Copper intake levels in the gut microbiota profile of target animals, in particular piglets": EFSA supporting publication 2016: EN-1024

Publikation: Bog/antologi/afhandling/rapportRapportForskning

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Extensive Literature Search on the “Effects of Copper intake levels in the gut microbiota profile of target animals, in particular piglets" : EFSA supporting publication 2016: EN-1024. / Jensen, Bent Borg.

European Food Safety Authority, 2016. 68 s.

Publikation: Bog/antologi/afhandling/rapportRapportForskning

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@book{da91d05a430344ec93c396937941cbe8,
title = "Extensive Literature Search on the “Effects of Copper intake levels in the gut microbiota profile of target animals, in particular piglets{"}: EFSA supporting publication 2016: EN-1024",
abstract = "The potential effect of the copper intake on the microbiota profile of pigs, chickens and cows wasreviewed through an extensive literature search. A total of 28 (out of 229), 17 (out of 106) and 0 (outof 114) references were considered relevant for pigs, chickens and cows, respectively. The overallconclusion from the studies with piglets and growing pigs is that copper, even at low concentrations(<50 mg/kg feed), may affect the microbiota in the gastrointestinal tract. Especially, the population ofclostridia and coliform bacteria seems to be affected by low copper concentrations. At higherconcentrations (>170 mg/kg feed) Cu as CuSO4 reduces the population of lactobacilli in piglets as wellas growing pigs. In slaughter pigs, the addition of Cu as CuSO4 reduces the population of streptococciin colonic and fecal samples, the population of ureolytic bacteria in the colon of which streptococcimake up 74%, the urease activity in the colon, and decarboxylation and deamination of amino acidsin the small intestine. No effect of Cu as CuSO4 on the population of streptococci and on ureaseactivity is seen in piglets. Supplementing piglet diets with 100 to 250 mg/kg Cu as CuSO4 significantlychange the community structure of the microbiota in the gastrointestinal tract by reducing the numberof bacterial species and reducing the similarity of the microbiota. The overall conclusion from thestudies with broilers is that copper, even at low concentrations (<50 mg/kg feed), may affect themicrobiota in the gastrointestinal tract. Especially the population of clostridia seems to be affected bylow copper concentrations. In particular, copper bound clay minerals seem to have an effect. Athigher concentrations (>200 mg/kg feed) inorganic or organic bound copper also seems to affect thepopulation of lactobacilli and coliform bacteria, to reduce the pH in gizzard content and to producesevere gizzard erosion",
keywords = "pigs, piglets, chickens, cows , copper, gastrointestinal tract, gut microbiota",
author = "Jensen, {Bent Borg}",
year = "2016",
month = may,
day = "2",
language = "English",
publisher = "European Food Safety Authority",

}

RIS

TY - RPRT

T1 - Extensive Literature Search on the “Effects of Copper intake levels in the gut microbiota profile of target animals, in particular piglets"

T2 - EFSA supporting publication 2016: EN-1024

AU - Jensen, Bent Borg

PY - 2016/5/2

Y1 - 2016/5/2

N2 - The potential effect of the copper intake on the microbiota profile of pigs, chickens and cows wasreviewed through an extensive literature search. A total of 28 (out of 229), 17 (out of 106) and 0 (outof 114) references were considered relevant for pigs, chickens and cows, respectively. The overallconclusion from the studies with piglets and growing pigs is that copper, even at low concentrations(<50 mg/kg feed), may affect the microbiota in the gastrointestinal tract. Especially, the population ofclostridia and coliform bacteria seems to be affected by low copper concentrations. At higherconcentrations (>170 mg/kg feed) Cu as CuSO4 reduces the population of lactobacilli in piglets as wellas growing pigs. In slaughter pigs, the addition of Cu as CuSO4 reduces the population of streptococciin colonic and fecal samples, the population of ureolytic bacteria in the colon of which streptococcimake up 74%, the urease activity in the colon, and decarboxylation and deamination of amino acidsin the small intestine. No effect of Cu as CuSO4 on the population of streptococci and on ureaseactivity is seen in piglets. Supplementing piglet diets with 100 to 250 mg/kg Cu as CuSO4 significantlychange the community structure of the microbiota in the gastrointestinal tract by reducing the numberof bacterial species and reducing the similarity of the microbiota. The overall conclusion from thestudies with broilers is that copper, even at low concentrations (<50 mg/kg feed), may affect themicrobiota in the gastrointestinal tract. Especially the population of clostridia seems to be affected bylow copper concentrations. In particular, copper bound clay minerals seem to have an effect. Athigher concentrations (>200 mg/kg feed) inorganic or organic bound copper also seems to affect thepopulation of lactobacilli and coliform bacteria, to reduce the pH in gizzard content and to producesevere gizzard erosion

AB - The potential effect of the copper intake on the microbiota profile of pigs, chickens and cows wasreviewed through an extensive literature search. A total of 28 (out of 229), 17 (out of 106) and 0 (outof 114) references were considered relevant for pigs, chickens and cows, respectively. The overallconclusion from the studies with piglets and growing pigs is that copper, even at low concentrations(<50 mg/kg feed), may affect the microbiota in the gastrointestinal tract. Especially, the population ofclostridia and coliform bacteria seems to be affected by low copper concentrations. At higherconcentrations (>170 mg/kg feed) Cu as CuSO4 reduces the population of lactobacilli in piglets as wellas growing pigs. In slaughter pigs, the addition of Cu as CuSO4 reduces the population of streptococciin colonic and fecal samples, the population of ureolytic bacteria in the colon of which streptococcimake up 74%, the urease activity in the colon, and decarboxylation and deamination of amino acidsin the small intestine. No effect of Cu as CuSO4 on the population of streptococci and on ureaseactivity is seen in piglets. Supplementing piglet diets with 100 to 250 mg/kg Cu as CuSO4 significantlychange the community structure of the microbiota in the gastrointestinal tract by reducing the numberof bacterial species and reducing the similarity of the microbiota. The overall conclusion from thestudies with broilers is that copper, even at low concentrations (<50 mg/kg feed), may affect themicrobiota in the gastrointestinal tract. Especially the population of clostridia seems to be affected bylow copper concentrations. In particular, copper bound clay minerals seem to have an effect. Athigher concentrations (>200 mg/kg feed) inorganic or organic bound copper also seems to affect thepopulation of lactobacilli and coliform bacteria, to reduce the pH in gizzard content and to producesevere gizzard erosion

KW - pigs

KW - piglets

KW - chickens

KW - cows

KW - copper

KW - gastrointestinal tract

KW - gut microbiota

UR - http://www.efsa.europa.eu/publications

M3 - Report

BT - Extensive Literature Search on the “Effects of Copper intake levels in the gut microbiota profile of target animals, in particular piglets"

PB - European Food Safety Authority

ER -