Exogenous Metallothionein Potentiates the Insulin Response at Normal Glucose Concentrations in INS-1E Beta Cells without disturbing Intracellular ZnT8 Expression

S B Nygaard; Ninna S Lund; Agnete Larsen; Nanna Pedersen; Jørgen Rungby; Kamille Smidt

doi:10.1111/bcpt.12287

Exogenous Metallothionein Potentiates the Insulin Response at Normal Glucose Concentrations in INS-1E Beta Cells without disturbing Intracellular ZnT8 Expression

S B Nygaard, Ninna S Lund, Agnete Larsen, Nanna Pedersen, Jørgen Rungby, Kamille Smidt

Institut for Biomedicin - Forskning og uddannelse, Øst

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

As a consequence of the global epidemic of obesity, the incidence of type 2 diabetes (T2D) is increasing worldwide. T2D is characterized by hyperglycaemia, hyper-insulinaemia and a reduced insulin response in muscular and fatty tissue. Over time, an increased insulin demand leads to cellular fatigue and death of the insulin producing β-cells. In response, the T2D patients become insulin-dependent and subjected to the boundaries of life-long insulin treatment. Preservation of β-cell insulin secretion and a sufficient β-cell mass is thus a corner stone in optimal TD2 treatment. This article is protected by copyright. All rights reserved.

Originalsprog	Engelsk
Bogserie	Basic & Clinical Pharmacology & Toxicology
Vol/bind	116
Nummer	2
Sider (fra-til)	173-177
Antal sider	5
ISSN	1742-7835
DOI	https://doi.org/10.1111/bcpt.12287
Status	Udgivet - feb. 2015

Adgang til dokumentet

10.1111/bcpt.12287

Citationsformater

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title = "Exogenous Metallothionein Potentiates the Insulin Response at Normal Glucose Concentrations in INS-1E Beta Cells without disturbing Intracellular ZnT8 Expression",

abstract = "As a consequence of the global epidemic of obesity, the incidence of type 2 diabetes (T2D) is increasing worldwide. T2D is characterized by hyperglycaemia, hyper-insulinaemia and a reduced insulin response in muscular and fatty tissue. Over time, an increased insulin demand leads to cellular fatigue and death of the insulin producing β-cells. In response, the T2D patients become insulin-dependent and subjected to the boundaries of life-long insulin treatment. Preservation of β-cell insulin secretion and a sufficient β-cell mass is thus a corner stone in optimal TD2 treatment. This article is protected by copyright. All rights reserved.",

author = "Nygaard, {S B} and Lund, {Ninna S} and Agnete Larsen and Nanna Pedersen and J{\o}rgen Rungby and Kamille Smidt",

year = "2015",

month = feb,

doi = "10.1111/bcpt.12287",

language = "English",

volume = "116",

pages = "173--177",

journal = "Basic & Clinical Pharmacology & Toxicology",

issn = "1742-7835",

publisher = "Wiley-Blackwell Publishing Ltd.",

number = "2",

}

Exogenous Metallothionein Potentiates the Insulin Response at Normal Glucose Concentrations in INS-1E Beta Cells without disturbing Intracellular ZnT8 Expression. / Nygaard, S B; Lund, Ninna S ; Larsen, Agnete et al.
I: Basic & Clinical Pharmacology & Toxicology, Bind 116, Nr. 2, 02.2015, s. 173-177.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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T1 - Exogenous Metallothionein Potentiates the Insulin Response at Normal Glucose Concentrations in INS-1E Beta Cells without disturbing Intracellular ZnT8 Expression

AU - Nygaard, S B

AU - Lund, Ninna S

AU - Larsen, Agnete

AU - Pedersen, Nanna

AU - Rungby, Jørgen

AU - Smidt, Kamille

PY - 2015/2

Y1 - 2015/2

N2 - As a consequence of the global epidemic of obesity, the incidence of type 2 diabetes (T2D) is increasing worldwide. T2D is characterized by hyperglycaemia, hyper-insulinaemia and a reduced insulin response in muscular and fatty tissue. Over time, an increased insulin demand leads to cellular fatigue and death of the insulin producing β-cells. In response, the T2D patients become insulin-dependent and subjected to the boundaries of life-long insulin treatment. Preservation of β-cell insulin secretion and a sufficient β-cell mass is thus a corner stone in optimal TD2 treatment. This article is protected by copyright. All rights reserved.

AB - As a consequence of the global epidemic of obesity, the incidence of type 2 diabetes (T2D) is increasing worldwide. T2D is characterized by hyperglycaemia, hyper-insulinaemia and a reduced insulin response in muscular and fatty tissue. Over time, an increased insulin demand leads to cellular fatigue and death of the insulin producing β-cells. In response, the T2D patients become insulin-dependent and subjected to the boundaries of life-long insulin treatment. Preservation of β-cell insulin secretion and a sufficient β-cell mass is thus a corner stone in optimal TD2 treatment. This article is protected by copyright. All rights reserved.

U2 - 10.1111/bcpt.12287

DO - 10.1111/bcpt.12287

M3 - Journal article

C2 - 24964825

SN - 1742-7835

VL - 116

SP - 173

EP - 177

JO - Basic & Clinical Pharmacology & Toxicology

JF - Basic & Clinical Pharmacology & Toxicology

IS - 2

ER -

Exogenous Metallothionein Potentiates the Insulin Response at Normal Glucose Concentrations in INS-1E Beta Cells without disturbing Intracellular ZnT8 Expression

Abstract

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