TY - JOUR
T1 - Exercise as medicine in Parkinson's disease
AU - Langeskov-Christensen, Martin
AU - Franzén, Erika
AU - Grøndahl Hvid, Lars
AU - Dalgas, Ulrik
PY - 2024/10/16
Y1 - 2024/10/16
N2 - Parkinson's disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while pharmacological symptomatic treatments have limited effects in certain domains and cause side effects. Identification of interventions that prevent, slow, halt or mitigate the disease is therefore pivotal. Exercise is safe and represents a cornerstone in PD rehabilitation, but exercise may have even more fundamental benefits that could change clinical practice. In PD, the existing knowledge base supports exercise as (1) a protective lifestyle factor preventing the disease (ie, primary prevention), (2) a potential disease-modifying therapy (ie, secondary prevention) and (3) an effective symptomatic treatment (ie, tertiary prevention). Based on current evidence, a paradigm shift is proposed, stating that exercise should be individually prescribed as medicine to persons with PD at an early disease stage, alongside conventional medical treatment.
AB - Parkinson's disease (PD) is an incurable and progressive neurological disorder leading to deleterious motor and non-motor consequences. Presently, no pharmacological agents can prevent PD evolution or progression, while pharmacological symptomatic treatments have limited effects in certain domains and cause side effects. Identification of interventions that prevent, slow, halt or mitigate the disease is therefore pivotal. Exercise is safe and represents a cornerstone in PD rehabilitation, but exercise may have even more fundamental benefits that could change clinical practice. In PD, the existing knowledge base supports exercise as (1) a protective lifestyle factor preventing the disease (ie, primary prevention), (2) a potential disease-modifying therapy (ie, secondary prevention) and (3) an effective symptomatic treatment (ie, tertiary prevention). Based on current evidence, a paradigm shift is proposed, stating that exercise should be individually prescribed as medicine to persons with PD at an early disease stage, alongside conventional medical treatment.
KW - Parkinson's disease
KW - clinical neurology
KW - movement disorders
KW - physiology
KW - physiotherapy
UR - http://www.scopus.com/inward/record.url?scp=85186868580&partnerID=8YFLogxK
U2 - 10.1136/jnnp-2023-332974
DO - 10.1136/jnnp-2023-332974
M3 - Review
C2 - 38418216
SN - 0022-3050
VL - 95
SP - 1077
EP - 1088
JO - Journal of Neurology, Neurosurgery & Psychiatry
JF - Journal of Neurology, Neurosurgery & Psychiatry
IS - 11
M1 - 23332974
ER -