Execution of new trajectories toward a stable goal without a functional hippocampus

Adrian J. Duszkiewicz; Janine I. Rossato; Andrea Moreno; Tomonori Takeuchi; Miwako Yamasaki; Lisa Genzel; Patrick Spooner; Santiago Canals; Richard G.M. Morris

doi:10.1002/hipo.23497

Execution of new trajectories toward a stable goal without a functional hippocampus

Adrian J. Duszkiewicz, Janine I. Rossato, Andrea Moreno, Tomonori Takeuchi, Miwako Yamasaki, Lisa Genzel, Patrick Spooner, Santiago Canals, Richard G.M. Morris^*

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

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Abstract

The hippocampus is a critical component of a mammalian spatial navigation system, with the firing sequences of hippocampal place cells during sleep or immobility constituting a “replay” of an animal's past trajectories. A novel spatial navigation task recently revealed that such “replay” sequences of place fields can also prospectively map onto imminent new paths to a goal that occupies a stable location during each session. It was hypothesized that such “prospective replay” sequences may play a causal role in goal-directed navigation. In the present study, we query this putative causal role in finding only minimal effects of muscimol-induced inactivation of the dorsal and intermediate hippocampus on the same spatial navigation task. The concentration of muscimol used demonstrably inhibited hippocampal cell firing in vivo and caused a severe deficit in a hippocampal-dependent “episodic-like” spatial memory task in a watermaze. These findings call into question whether “prospective replay” of an imminent and direct path is actually necessary for its execution in certain navigational tasks.

Originalsprog	Engelsk
Tidsskrift	Hippocampus
Vol/bind	33
Nummer	6
Sider (fra-til)	769-786
Antal sider	18
ISSN	1050-9631
DOI	https://doi.org/10.1002/hipo.23497
Status	Udgivet - jun. 2023

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10.1002/hipo.23497Licens: CC BY

Hippocampus - 2023 - Duszkiewicz - Execution of new trajectories toward a stable goal without a functional hippocampusForlagets udgivne version, 3,28 MBLicens: CC BY

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title = "Execution of new trajectories toward a stable goal without a functional hippocampus",

abstract = "The hippocampus is a critical component of a mammalian spatial navigation system, with the firing sequences of hippocampal place cells during sleep or immobility constituting a “replay” of an animal's past trajectories. A novel spatial navigation task recently revealed that such “replay” sequences of place fields can also prospectively map onto imminent new paths to a goal that occupies a stable location during each session. It was hypothesized that such “prospective replay” sequences may play a causal role in goal-directed navigation. In the present study, we query this putative causal role in finding only minimal effects of muscimol-induced inactivation of the dorsal and intermediate hippocampus on the same spatial navigation task. The concentration of muscimol used demonstrably inhibited hippocampal cell firing in vivo and caused a severe deficit in a hippocampal-dependent “episodic-like” spatial memory task in a watermaze. These findings call into question whether “prospective replay” of an imminent and direct path is actually necessary for its execution in certain navigational tasks.",

keywords = "electrophysiology, hippocampus, pharmacology, spatial learning, spatial navigation",

author = "Duszkiewicz, {Adrian J.} and Rossato, {Janine I.} and Andrea Moreno and Tomonori Takeuchi and Miwako Yamasaki and Lisa Genzel and Patrick Spooner and Santiago Canals and Morris, {Richard G.M.}",

note = "Publisher Copyright: {\textcopyright} 2023 The Authors. Hippocampus published by Wiley Periodicals LLC.",

year = "2023",

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AU - Duszkiewicz, Adrian J.

AU - Rossato, Janine I.

AU - Moreno, Andrea

AU - Takeuchi, Tomonori

AU - Yamasaki, Miwako

AU - Genzel, Lisa

AU - Spooner, Patrick

AU - Canals, Santiago

AU - Morris, Richard G.M.

PY - 2023/6

Y1 - 2023/6

N2 - The hippocampus is a critical component of a mammalian spatial navigation system, with the firing sequences of hippocampal place cells during sleep or immobility constituting a “replay” of an animal's past trajectories. A novel spatial navigation task recently revealed that such “replay” sequences of place fields can also prospectively map onto imminent new paths to a goal that occupies a stable location during each session. It was hypothesized that such “prospective replay” sequences may play a causal role in goal-directed navigation. In the present study, we query this putative causal role in finding only minimal effects of muscimol-induced inactivation of the dorsal and intermediate hippocampus on the same spatial navigation task. The concentration of muscimol used demonstrably inhibited hippocampal cell firing in vivo and caused a severe deficit in a hippocampal-dependent “episodic-like” spatial memory task in a watermaze. These findings call into question whether “prospective replay” of an imminent and direct path is actually necessary for its execution in certain navigational tasks.

AB - The hippocampus is a critical component of a mammalian spatial navigation system, with the firing sequences of hippocampal place cells during sleep or immobility constituting a “replay” of an animal's past trajectories. A novel spatial navigation task recently revealed that such “replay” sequences of place fields can also prospectively map onto imminent new paths to a goal that occupies a stable location during each session. It was hypothesized that such “prospective replay” sequences may play a causal role in goal-directed navigation. In the present study, we query this putative causal role in finding only minimal effects of muscimol-induced inactivation of the dorsal and intermediate hippocampus on the same spatial navigation task. The concentration of muscimol used demonstrably inhibited hippocampal cell firing in vivo and caused a severe deficit in a hippocampal-dependent “episodic-like” spatial memory task in a watermaze. These findings call into question whether “prospective replay” of an imminent and direct path is actually necessary for its execution in certain navigational tasks.

KW - electrophysiology

KW - hippocampus

KW - pharmacology

KW - spatial learning

KW - spatial navigation

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DO - 10.1002/hipo.23497

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AN - SCOPUS:85148436855

SN - 1050-9631

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SP - 769

EP - 786

JO - Hippocampus

JF - Hippocampus

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ER -

Execution of new trajectories toward a stable goal without a functional hippocampus

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