Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

Mette Falkenberg Krantz; Carsten Hjorthøj; Ditte Ellersgaard; Nicoline Hemager; Camilla Christiani; Katrine Søborg Spang; Birgitte Klee Burton; Maja Gregersen; Anne Søndergaard; Aja Greve; Jessica Ohland; Preben Bo Mortensen; Kerstin Jessica Plessen; Vibeke Bliksted; Jens Richardt Møllegaard Jepsen; Anne A E Thorup; Ole Mors; Merete Nordentoft

doi:10.1007/s00127-022-02338-3

Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

Mette Falkenberg Krantz^*, Carsten Hjorthøj, Ditte Ellersgaard, Nicoline Hemager, Camilla Christiani, Katrine Søborg Spang, Birgitte Klee Burton, Maja Gregersen, Anne Søndergaard, Aja Greve, Jessica Ohland, Preben Bo Mortensen, Kerstin Jessica Plessen, Vibeke Bliksted, Jens Richardt Møllegaard Jepsen, Anne A E Thorup, Ole Mors, Merete Nordentoft

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

4 Citationer (Scopus)

Abstract

PURPOSE: Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.

METHODS: Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.

RESULTS: In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0.04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p ≤ 0.01 for maternal FHR-SZ and FHR-BP, p = 0.001 for paternal FHR-BP). Inverse probability weighted analyses of results generated from the VIA Study showed minor changes in study findings after adjustment for the found selection bias.

CONCLUSIONS: Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.

Originalsprog	Engelsk
Tidsskrift	Social Psychiatry and Psychiatric Epidemiology
Vol/bind	58
Nummer	1
Sider (fra-til)	113-140
Antal sider	28
ISSN	0933-7954
DOI	https://doi.org/10.1007/s00127-022-02338-3
Status	Udgivet - jan. 2023

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10.1007/s00127-022-02338-3

Citationsformater

Krantz, M. F., Hjorthøj, C., Ellersgaard, D., Hemager, N., Christiani, C., Spang, K. S., Burton, B. K., Gregersen, M., Søndergaard, A., Greve, A., Ohland, J., Mortensen, P. B., Plessen, K. J., Bliksted, V., Jepsen, J. R. M., Thorup, A. A. E., Mors, O., & Nordentoft, M. (2023). Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7. Social Psychiatry and Psychiatric Epidemiology, 58(1), 113-140. https://doi.org/10.1007/s00127-022-02338-3

@article{cfa3ac63797844049dc4de735e5437c4,

title = "Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7",

abstract = "PURPOSE: Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.METHODS: Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.RESULTS: In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0.04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p ≤ 0.01 for maternal FHR-SZ and FHR-BP, p = 0.001 for paternal FHR-BP). Inverse probability weighted analyses of results generated from the VIA Study showed minor changes in study findings after adjustment for the found selection bias.CONCLUSIONS: Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.",

keywords = "Familial high-risk, Generalizability, Representativity, Severe parental mental illness, Socio-economy",

author = "Krantz, {Mette Falkenberg} and Carsten Hjorth{\o}j and Ditte Ellersgaard and Nicoline Hemager and Camilla Christiani and Spang, {Katrine S{\o}borg} and Burton, {Birgitte Klee} and Maja Gregersen and Anne S{\o}ndergaard and Aja Greve and Jessica Ohland and Mortensen, {Preben Bo} and Plessen, {Kerstin Jessica} and Vibeke Bliksted and Jepsen, {Jens Richardt M{\o}llegaard} and Thorup, {Anne A E} and Ole Mors and Merete Nordentoft",

year = "2023",

month = jan,

doi = "10.1007/s00127-022-02338-3",

language = "English",

volume = "58",

pages = "113--140",

journal = "Social Psychiatry and Psychiatric Epidemiology",

issn = "0933-7954",

publisher = "Springer Medizin",

number = "1",

}

Krantz, MF, Hjorthøj, C, Ellersgaard, D, Hemager, N, Christiani, C, Spang, KS, Burton, BK, Gregersen, M, Søndergaard, A, Greve, A, Ohland, J, Mortensen, PB, Plessen, KJ, Bliksted, V, Jepsen, JRM, Thorup, AAE, Mors, O & Nordentoft, M 2023, 'Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7', Social Psychiatry and Psychiatric Epidemiology, bind 58, nr. 1, s. 113-140. https://doi.org/10.1007/s00127-022-02338-3

Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7. / Krantz, Mette Falkenberg; Hjorthøj, Carsten; Ellersgaard, Ditte et al.
I: Social Psychiatry and Psychiatric Epidemiology, Bind 58, Nr. 1, 01.2023, s. 113-140.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls

T2 - The Danish High Risk and Resilience Study VIA 7

AU - Krantz, Mette Falkenberg

AU - Hjorthøj, Carsten

AU - Ellersgaard, Ditte

AU - Hemager, Nicoline

AU - Christiani, Camilla

AU - Spang, Katrine Søborg

AU - Burton, Birgitte Klee

AU - Gregersen, Maja

AU - Søndergaard, Anne

AU - Greve, Aja

AU - Ohland, Jessica

AU - Mortensen, Preben Bo

AU - Plessen, Kerstin Jessica

AU - Bliksted, Vibeke

AU - Jepsen, Jens Richardt Møllegaard

AU - Thorup, Anne A E

AU - Mors, Ole

AU - Nordentoft, Merete

PY - 2023/1

Y1 - 2023/1

N2 - PURPOSE: Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.METHODS: Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.RESULTS: In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0.04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p ≤ 0.01 for maternal FHR-SZ and FHR-BP, p = 0.001 for paternal FHR-BP). Inverse probability weighted analyses of results generated from the VIA Study showed minor changes in study findings after adjustment for the found selection bias.CONCLUSIONS: Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.

AB - PURPOSE: Knowledge about representativity of familial high-risk studies of schizophrenia and bipolar disorder is essential to generalize study conclusions. The Danish High Risk and Resilience Study (VIA 7), a population-based case-control familial high-risk study, creates a unique opportunity for combining assessment and register data to examine cohort representativity.METHODS: Through national registers, we identified the population of 11,959 children of parents with schizophrenia (FHR-SZ) or bipolar disorder (FHR-BP) and controls from which the 522 children participating in The VIA 7 Study (202 FHR-SZ, 120 FHR-BP and 200 controls) were selected. Socio-economic and health data were obtained to compare high-risk groups and controls, and participants versus non-participants. Selection bias impact on results was analyzed through inverse probability weights.RESULTS: In the total sample of 11,959 children, FHR-SZ and FHR-BP children had more socio-economic and health disadvantages than controls (p < 0.001 for most). VIA 7 non-participants had a poorer function, e.g. more paternal somatic and mental illness (p = 0.02 and p = 0.04 for FHR-SZ), notifications of concern (FHR-BP and PBC p < 0.001), placements out of home (p = 0.03 for FHR-SZ), and lower level of education (p ≤ 0.01 for maternal FHR-SZ and FHR-BP, p = 0.001 for paternal FHR-BP). Inverse probability weighted analyses of results generated from the VIA Study showed minor changes in study findings after adjustment for the found selection bias.CONCLUSIONS: Familial high-risk families have multiple socio-economic and health disadvantages. In The VIA 7 Study, although comparable regarding mental illness severity after their child's birth, socioeconomic and health disadvantages are more profound amongst non-participants than amongst participants.

KW - Familial high-risk

KW - Generalizability

KW - Representativity

KW - Severe parental mental illness

KW - Socio-economy

U2 - 10.1007/s00127-022-02338-3

DO - 10.1007/s00127-022-02338-3

M3 - Journal article

C2 - 36087138

SN - 0933-7954

VL - 58

SP - 113

EP - 140

JO - Social Psychiatry and Psychiatric Epidemiology

JF - Social Psychiatry and Psychiatric Epidemiology

IS - 1

ER -

Krantz MF, Hjorthøj C, Ellersgaard D, Hemager N, Christiani C, Spang KS et al. Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7. Social Psychiatry and Psychiatric Epidemiology. 2023 jan.;58(1):113-140. Epub 2022 sep. 10. doi: 10.1007/s00127-022-02338-3

Examining selection bias in a population-based cohort study of 522 children with familial high risk of schizophrenia or bipolar disorder, and controls: The Danish High Risk and Resilience Study VIA 7

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