Evidence for increased genetic risk load for major depression in patients assigned to electroconvulsive therapy

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  • Jerome C. Foo, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat
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  • Fabian Streit, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat
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  • Josef Frank, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat
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  • Jens Treutlein, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat
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  • Bernhard T. Baune, Univ Melbourne, University of Melbourne, Melbourne Med Sch, Dept Psychiat
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  • Susanne Moebus, Univ Duisburg Essen, University of Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol
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  • Karl-Heinz Joeckel, Univ Duisburg Essen, University of Duisburg Essen, Univ Hosp Essen, Inst Med Informat Biometry & Epidemiol
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  • Andreas J. Forstner, Univ Basel, University of Basel, Dept Biomed, Human Genom Res Grp
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  • Markus M. Noethen, Univ Bonn, University of Bonn, Dept Genom, Life & Brain Ctr
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  • Marcella Rietschel, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Genet Epidemiol Psychiat
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  • Alexander Sartorius, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Cent Inst Mental Hlth
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  • Laura Kranaster, Heidelberg Univ, Central Institute of Mental Health, Ruprecht Karls University Heidelberg, Med Fac Mannheim, Dept Psychiat & Psychotherapy, Cent Inst Mental Hlth
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  • Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium (Jakob Grove, member of -)

Electroconvulsive therapy (ECT) is the treatment of choice for severe and treatment-resistant depression; disorder severity and unfavorable treatment outcomes are shown to be influenced by an increased genetic burden for major depression (MD). Here, we tested whether ECT assignment and response/nonresponse are associated with an increased genetic burden for major depression (MD) using polygenic risk score (PRS), which summarize the contribution of disease-related common risk variants. Fifty-one psychiatric inpatients suffering from a major depressive episode underwent ECT. MD-PRS were calculated for these inpatients and a separate population-based sample (n = 3,547 healthy; n = 426 self-reported depression) based on summary statistics from the Psychiatric Genomics Consortium MDD-working group (Cases: n = 59,851; Controls: n = 113,154). MD-PRS explained a significant proportion of disease status between ECT patients and healthy controls (p = .022, R-2 = 1.173%); patients showed higher MD-PRS. MD-PRS in population-based depression self-reporters were intermediate between ECT patients and controls (n.s.). Significant associations between MD-PRS and ECT response (50% reduction in Hamilton depression rating scale scores) were not observed. Our findings indicate that ECT cohorts show an increased genetic burden for MD and are consistent with the hypothesis that treatment-resistant MD patients represent a subgroup with an increased genetic risk for MD. Larger samples are needed to better substantiate these findings.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Medical Genetics. Part B: Neuropsychiatric Genetics
Vol/bind180
Nummer1
Sider (fra-til)35-45
Antal sider11
ISSN1552-4841
DOI
StatusUdgivet - jan. 2019

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