European Expert Consensus on Practical Management of Specific Aspects of Parathyroid Disorders in Adults and in Pregnancy: recommendations of the ESE Educational Program of Parathyroid Disorders

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

  • Jens Bollerslev, University of Oslo, Section of Specialized Endocrinology, Medical Clinic
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  • Lars Rejnmark
  • Alexandra Zahn, A Zahn
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  • Ansgar Heck, University of Oslo
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  • N M Appelman-Dijkstra, N Appelman-Dijkstra
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  • Luis Cardoso, Centro Hospitalar e Universitário de Coimbra EPE
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  • Fadil M Hannan, University of Oxford
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  • Filomena Cetani, University of Pisa
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  • Anna Maria Formenti, Vita-Salute San Raffaele University
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  • Sigridur Björnsdottir, Karolinska Institutet
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  • Camilla Schalin-Jantti, University of Helsinki
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  • Zhanna Belaya, Syddansk Universitet
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  • Fraser Wilson Gibb, F Gibb
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  • Bruno Lapauw, Ghent University
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  • Karin Amrein, Medical University of Graz
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  • Corinna Wicke, Kantonsspital Luzern
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  • Corinna Grasemann, Ruhr University Bochum
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  • Michael Krebs, Medical University of Vienna
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  • Eeva M Ryhänen, University of Helsinki
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  • Ozer Makay, Ege Univ Hosp, Ege University, Dept Pulmonol
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  • Salvatore Minisola, University of Rome La Sapienza
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  • Sebastien Gaujoux, S Gaujoux
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  • Jean-Philippe Bertocchio, Department of Cardiology, University Hospital Pitié-Salpêtrière, Paris, France.
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  • Zaki K Hassan-Smith, University Hospitals Birmingham NHS Foundation Trust
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  • Agnès Linglart, Universite Paris-Sud
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  • Elizabeth M Winter, Leiden University
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  • Martina Kollmann, Medical University of Graz
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  • Hans-Georg Zmierczak, Ghent Universitary Hospital
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  • Elena Tsourdi, Division of Rheumatology, Department of Medicine III, University Medical Center & Faculty of Medicine Carl Gustav Carus, Technical University of Dresden, Dresden, Germany.
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  • Stefan Pilz, Medical University of Graz
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  • Heide Siggelkow, University of Göttingen
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  • Neil J Gittoes, University Hospitals Birmingham NHS Foundation Trust
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  • Claudio Marcocci, University of Pisa
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  • Peter Kamenicky, P Kamenicky
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  • PARAT Working Group

This European expert consensus statement provides recommendations for the diagnosis and management of primary hyperparathyroidism (PHPT), chronic hypoparathyroidism in adults (HypoPT), and parathyroid disorders in relation to pregnancy and lactation. Specified areas of interest and unmet needs identified by experts at the second ESE Educational Program of Parathyroid Disorders in 2019 were discussed during two virtual workshops in 2021 and subsequently developed by working groups with interest in t he specified areas. PHPT is a common endocrine disease. However, its differential diagnosis of familial hypocal ciuric hypercalcemia (FHH), the definition and clinical course of normocalcemic PHPT, and the optimal management of its recurrence after surgery represents areas of uncertainty requiring clarifications. HypoPT is an orphan diseas e characterized by low calcium concentrations due to insufficient PTH secretion, most often secondary to neck surge ry. Prevention and prediction of surgical injury to the parathyroid glands are essential to limit the disease-related burden. Long-term treatment modalities including the place for PTH replacement therapy and the optimal biochemical monitoring and imaging surveillance for complications to treatment in chronic HypoPT need to be refined. The physiological changes in calcium metabolism occurring during pregnancy and lactation modify the clinical presentation and management of parathyroid disorders in these periods of life. Modern interdisciplinary approaches to PHPT and HypoPT in pregnant and lactating women and their newborn children are proposed. The recommendations on clinical management presented here will serve as background for further educational material aimed at a broader clinical audience and were developed with the focus on endocrinologists in training.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Endocrinology
Vol/bind186
Nummer2
Sider (fra-til)R33-R63
ISSN0804-4643
DOI
StatusUdgivet - feb. 2022

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