Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS)

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Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS). / Østergaard, Søren D; Rothschild, Anthony J; Flint, Alastair J; Mulsant, Benoit H; Whyte, Ellen M; Vermeulen, Tom; Bech, Per; Meyers, Barnett S.

I: Journal of Affective Disorders, Bind 190, Nr. 15, 01.2016, s. 111-114.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisLetterForskningpeer review

Harvard

Østergaard, SD, Rothschild, AJ, Flint, AJ, Mulsant, BH, Whyte, EM, Vermeulen, T, Bech, P & Meyers, BS 2016, 'Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS)', Journal of Affective Disorders, bind 190, nr. 15, s. 111-114. https://doi.org/10.1016/j.jad.2015.09.073

APA

Østergaard, S. D., Rothschild, A. J., Flint, A. J., Mulsant, B. H., Whyte, E. M., Vermeulen, T., Bech, P., & Meyers, B. S. (2016). Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS). Journal of Affective Disorders, 190(15), 111-114. https://doi.org/10.1016/j.jad.2015.09.073

CBE

Østergaard SD, Rothschild AJ, Flint AJ, Mulsant BH, Whyte EM, Vermeulen T, Bech P, Meyers BS. 2016. Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS). Journal of Affective Disorders. 190(15):111-114. https://doi.org/10.1016/j.jad.2015.09.073

MLA

Vancouver

Østergaard SD, Rothschild AJ, Flint AJ, Mulsant BH, Whyte EM, Vermeulen T o.a. Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS). Journal of Affective Disorders. 2016 jan;190(15):111-114. https://doi.org/10.1016/j.jad.2015.09.073

Author

Østergaard, Søren D ; Rothschild, Anthony J ; Flint, Alastair J ; Mulsant, Benoit H ; Whyte, Ellen M ; Vermeulen, Tom ; Bech, Per ; Meyers, Barnett S. / Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS). I: Journal of Affective Disorders. 2016 ; Bind 190, Nr. 15. s. 111-114.

Bibtex

@article{8b241c8432d24d00a56bde4c5203571f,
title = "Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS)",
abstract = "BACKGROUND: The Psychotic Depression Assessment Scale (PDAS) is a rating scale dedicated to the measurement of severity in psychotic depression (PD). The aim of this study was to establish the PDAS cut-off for remission of PD as well as PDAS score-ranges for mild, moderate, and severe PD. The secondary aim was to test how remission, as defined by the PDAS, would perform as outcome measure when applied to the data from a large randomized controlled trial (RCT) in PD.METHODS: The study was based on data from the Study of Pharmacotherapy in Psychotic Depression (STOP-PD). The cut-off for remission on the PDAS and the severity-ranges for mild, moderate, and severe PD were defined using the Clinical Global Impression - Severity scale (CGI-S) as reference by means of pair-wise receiver operating characteristic (ROC) analyses. Subsequently, it was tested whether remission on the PDAS could separate the effects of Olanzapine+Sertraline vs. Olanzapine+Placebo through an intention-to-treat, mixed-effects logistic regression of the data from STOP-PD.RESULTS: According to the ROC analyses, the ideal cut-off for remission of PD was a PDAS total score <8, while the severity-ranges for mild, moderate and severe PD were 8-15, 16-23, and >23 respectively. When applying the PDAS total score <8 (remission) as outcome on the STOP-PD data, treatment with Olanzapine+Sertraline performed significantly better than Olanzapine+Placebo (p<0.001).LIMITATIONS: The STOP-PD was not designed specifically to answer the research questions of the present study.CONCLUSIONS: According to this study, a total score <8 on the PDAS corresponds to remission of PD.",
author = "{\O}stergaard, {S{\o}ren D} and Rothschild, {Anthony J} and Flint, {Alastair J} and Mulsant, {Benoit H} and Whyte, {Ellen M} and Tom Vermeulen and Per Bech and Meyers, {Barnett S}",
note = "Copyright {\textcopyright} 2015 Elsevier B.V. All rights reserved.",
year = "2016",
month = jan,
doi = "10.1016/j.jad.2015.09.073",
language = "English",
volume = "190",
pages = "111--114",
journal = "Journal of Affective Disorders",
issn = "0165-0327",
publisher = "Elsevier BV",
number = "15",

}

RIS

TY - JOUR

T1 - Establishing the cut-off score for remission and severity-ranges on the Psychotic Depression Assessment Scale (PDAS)

AU - Østergaard, Søren D

AU - Rothschild, Anthony J

AU - Flint, Alastair J

AU - Mulsant, Benoit H

AU - Whyte, Ellen M

AU - Vermeulen, Tom

AU - Bech, Per

AU - Meyers, Barnett S

N1 - Copyright © 2015 Elsevier B.V. All rights reserved.

PY - 2016/1

Y1 - 2016/1

N2 - BACKGROUND: The Psychotic Depression Assessment Scale (PDAS) is a rating scale dedicated to the measurement of severity in psychotic depression (PD). The aim of this study was to establish the PDAS cut-off for remission of PD as well as PDAS score-ranges for mild, moderate, and severe PD. The secondary aim was to test how remission, as defined by the PDAS, would perform as outcome measure when applied to the data from a large randomized controlled trial (RCT) in PD.METHODS: The study was based on data from the Study of Pharmacotherapy in Psychotic Depression (STOP-PD). The cut-off for remission on the PDAS and the severity-ranges for mild, moderate, and severe PD were defined using the Clinical Global Impression - Severity scale (CGI-S) as reference by means of pair-wise receiver operating characteristic (ROC) analyses. Subsequently, it was tested whether remission on the PDAS could separate the effects of Olanzapine+Sertraline vs. Olanzapine+Placebo through an intention-to-treat, mixed-effects logistic regression of the data from STOP-PD.RESULTS: According to the ROC analyses, the ideal cut-off for remission of PD was a PDAS total score <8, while the severity-ranges for mild, moderate and severe PD were 8-15, 16-23, and >23 respectively. When applying the PDAS total score <8 (remission) as outcome on the STOP-PD data, treatment with Olanzapine+Sertraline performed significantly better than Olanzapine+Placebo (p<0.001).LIMITATIONS: The STOP-PD was not designed specifically to answer the research questions of the present study.CONCLUSIONS: According to this study, a total score <8 on the PDAS corresponds to remission of PD.

AB - BACKGROUND: The Psychotic Depression Assessment Scale (PDAS) is a rating scale dedicated to the measurement of severity in psychotic depression (PD). The aim of this study was to establish the PDAS cut-off for remission of PD as well as PDAS score-ranges for mild, moderate, and severe PD. The secondary aim was to test how remission, as defined by the PDAS, would perform as outcome measure when applied to the data from a large randomized controlled trial (RCT) in PD.METHODS: The study was based on data from the Study of Pharmacotherapy in Psychotic Depression (STOP-PD). The cut-off for remission on the PDAS and the severity-ranges for mild, moderate, and severe PD were defined using the Clinical Global Impression - Severity scale (CGI-S) as reference by means of pair-wise receiver operating characteristic (ROC) analyses. Subsequently, it was tested whether remission on the PDAS could separate the effects of Olanzapine+Sertraline vs. Olanzapine+Placebo through an intention-to-treat, mixed-effects logistic regression of the data from STOP-PD.RESULTS: According to the ROC analyses, the ideal cut-off for remission of PD was a PDAS total score <8, while the severity-ranges for mild, moderate and severe PD were 8-15, 16-23, and >23 respectively. When applying the PDAS total score <8 (remission) as outcome on the STOP-PD data, treatment with Olanzapine+Sertraline performed significantly better than Olanzapine+Placebo (p<0.001).LIMITATIONS: The STOP-PD was not designed specifically to answer the research questions of the present study.CONCLUSIONS: According to this study, a total score <8 on the PDAS corresponds to remission of PD.

U2 - 10.1016/j.jad.2015.09.073

DO - 10.1016/j.jad.2015.09.073

M3 - Letter

C2 - 26496016

VL - 190

SP - 111

EP - 114

JO - Journal of Affective Disorders

JF - Journal of Affective Disorders

SN - 0165-0327

IS - 15

ER -