Establishing stress response profiles in ageing human cells as markers of health

Publikation: Bog/antologi/afhandling/rapportPh.d.-afhandlingForskning

  • Dino Demirovic, Danmark
OriginalsprogEngelsk
Rekvirerende organGraduate School of Science and Technology
StatusUdgivet - 26 aug. 2015

Note vedr. afhandling

The Darwinian purpose of life for a biological system is reproduction and continuation of generations. Once this purpose is fulfilled, the fate of the individual is uncertain and sooner or later every individual faces death. No organism, at an individual level, has ever been shown to live forever, and therefore the consequence of life is given.

During his studies, Dino Demirovic has been doing research in trying to understand how and why human cells lose their youthfulness and become old. One of the main characteristics of the young cells is their ability to tolerate stress, while the old cells cannot do so effectively. To understand these changes, Dino Demirovic has during his studies and research developed a new method to determine seven different cellular stress response pathways simultaneously. This can been used to create stress response profiles of healthy young and old cells, which can be useful to determine the state of health and the biological age of an individual.

PhD degree was completed at the Laboratory of Cellular Ageing, Department of Molecular Biology and Genetics, Faculty of Science and Technology, Aarhus University.

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