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Epigenetic and Transcriptional Regulation of Spontaneous and Sensory Activity Dependent Programs During Neuronal Circuit Development

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

DOI

  • Gabriele M Pumo, Friedrich Miescher Institute for Biomedical Research
    • ,
  • Taro Kitazawa
  • Filippo M Rijli, Friedrich Miescher Institute for Biomedical Research

Spontaneous activity generated before the onset of sensory transduction has a key role in wiring developing sensory circuits. From axonal targeting, to synapse formation and elimination, to the balanced integration of neurons into developing circuits, this type of activity is implicated in a variety of cellular processes. However, little is known about its molecular mechanisms of action, especially at the level of genome regulation. Conversely, sensory experience-dependent activity implements well-characterized transcriptional and epigenetic chromatin programs that underlie heterogeneous but specific genomic responses that shape both postnatal circuit development and neuroplasticity in the adult. In this review, we focus on our knowledge of the developmental processes regulated by spontaneous activity and the underlying transcriptional mechanisms. We also review novel findings on how chromatin regulates the specificity and developmental induction of the experience-dependent program, and speculate their relevance for our understanding of how spontaneous activity may act at the genomic level to instruct circuit assembly and prepare developing neurons for sensory-dependent connectivity refinement and processing.

OriginalsprogEngelsk
Artikelnummer911023
TidsskriftFrontiers in Neural Circuits
Vol/bind16
Sider (fra-til)21
ISSN1662-5110
DOI
StatusUdgivet - maj 2022
Eksternt udgivetJa

Bibliografisk note

Copyright © 2022 Pumo, Kitazawa and Rijli.

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