Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study

Marie Westergaard-Nielsen; Christian Godballe; Jesper Grau Eriksen; Stine Rosenkilde Larsen; Katalin Kiss; Tina Agander; Benedicte Parm Ulhøi; Birgitte Wittenborg Charabi; Tejs Ehlers Klug; Henrik Jacobsen; Jørgen Johansen; Claus Andrup Kristensen; Elo Andersen; Maria Andersen; Kristine Bjørndal

doi:10.1007/s00405-023-07940-y

Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study

Marie Westergaard-Nielsen^*, Christian Godballe, Jesper Grau Eriksen, Stine Rosenkilde Larsen, Katalin Kiss, Tina Agander, Benedicte Parm Ulhøi, Birgitte Wittenborg Charabi, Tejs Ehlers Klug, Henrik Jacobsen, Jørgen Johansen, Claus Andrup Kristensen, Elo Andersen, Maria Andersen, Kristine Bjørndal

^*Corresponding author af dette arbejde

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

Abstract

PURPOSE: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma.

METHODS: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression.

RESULTS: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11-102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates.

CONCLUSION: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.

Originalsprog	Engelsk
Tidsskrift	European Archives of Oto-Rhino-Laryngology
Vol/bind	280
Nummer	7
Sider (fra-til)	3405-3413
Antal sider	9
DOI	https://doi.org/10.1007/s00405-023-07940-y
Status	Udgivet - jul. 2023

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10.1007/s00405-023-07940-yLicens: CC BY

Citationsformater

Westergaard-Nielsen, M., Godballe, C., Eriksen, J. G., Larsen, S. R., Kiss, K., Agander, T., Ulhøi, B. P., Charabi, B. W., Klug, T. E., Jacobsen, H., Johansen, J., Kristensen, C. A., Andersen, E., Andersen, M., & Bjørndal, K. (2023). Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study. European Archives of Oto-Rhino-Laryngology, 280(7), 3405-3413. https://doi.org/10.1007/s00405-023-07940-y

@article{95b8f6c9e92c4b83aa9307baa994c6e9,

title = "Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study",

abstract = "PURPOSE: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma.METHODS: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression.RESULTS: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11-102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates.CONCLUSION: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.",

keywords = "Salivary gland carcinoma, Submandibular gland cancer, Submandibular gland carcinoma",

author = "Marie Westergaard-Nielsen and Christian Godballe and Eriksen, {Jesper Grau} and Larsen, {Stine Rosenkilde} and Katalin Kiss and Tina Agander and Ulh{\o}i, {Benedicte Parm} and Charabi, {Birgitte Wittenborg} and Klug, {Tejs Ehlers} and Henrik Jacobsen and J{\o}rgen Johansen and Kristensen, {Claus Andrup} and Elo Andersen and Maria Andersen and Kristine Bj{\o}rndal",

note = "{\textcopyright} 2023. The Author(s).",

year = "2023",

month = jul,

doi = "10.1007/s00405-023-07940-y",

language = "English",

volume = "280",

pages = "3405--3413",

journal = "European Archives of Oto-Rhino-Laryngology",

issn = "0942-8992",

publisher = "Springer",

number = "7",

}

Westergaard-Nielsen, M, Godballe, C, Eriksen, JG, Larsen, SR, Kiss, K, Agander, T, Ulhøi, BP, Charabi, BW, Klug, TE, Jacobsen, H, Johansen, J, Kristensen, CA, Andersen, E, Andersen, M & Bjørndal, K 2023, 'Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study', European Archives of Oto-Rhino-Laryngology, bind 280, nr. 7, s. 3405-3413. https://doi.org/10.1007/s00405-023-07940-y

Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study. / Westergaard-Nielsen, Marie; Godballe, Christian; Eriksen, Jesper Grau et al.
I: European Archives of Oto-Rhino-Laryngology, Bind 280, Nr. 7, 07.2023, s. 3405-3413.

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Tidsskriftartikel › Forskning › peer review

TY - JOUR

T1 - Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas

T2 - a national DAHANCA study

AU - Westergaard-Nielsen, Marie

AU - Godballe, Christian

AU - Eriksen, Jesper Grau

AU - Larsen, Stine Rosenkilde

AU - Kiss, Katalin

AU - Agander, Tina

AU - Ulhøi, Benedicte Parm

AU - Charabi, Birgitte Wittenborg

AU - Klug, Tejs Ehlers

AU - Jacobsen, Henrik

AU - Johansen, Jørgen

AU - Kristensen, Claus Andrup

AU - Andersen, Elo

AU - Andersen, Maria

AU - Bjørndal, Kristine

PY - 2023/7

Y1 - 2023/7

N2 - PURPOSE: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma.METHODS: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression.RESULTS: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11-102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates.CONCLUSION: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.

AB - PURPOSE: The aim of this study is to present incidence, histological subtypes, survival rates, and prognostic factors based on a national cohort of patients with salivary gland carcinoma.METHODS: All Danish patients with submandibular gland carcinoma diagnosed from 1990 to 2015 (n = 206) were included and analyzed following histological re-evaluation. Data were collected by the Danish Head and Neck Cancer Group (DAHANCA). Overall, disease-specific and recurrence-free survival were evaluated. Prognostic factors were analyzed with multivariate Cox Hazard Regression.RESULTS: The study population consisted of 109 (53%) men and 97 (47%) women, median age 62 years (range 11-102). Adenoid cystic carcinoma was the most frequent subtype (50%). Tumour classification T1/T2 (75%) and N0 (78%) was most frequent. The mean crude incidence was 0.17/100,000/year. Most patients (n = 194, 94%) were treated with primary surgery, and 130 (67%) received postoperative radiotherapy. The 5- and 10-year survival rates were for overall survival 64% and 41%, disease-specific survival 74% and 61%, and recurrence-free survival 70% and 56%, respectively. Survival rates were higher for adenoid cystic carcinoma compared to other subtypes, but the difference was not significant in multivariate analysis. Recurrence occurred in 69 patients, and 37 (53.6%) of them had recurrence in a distant site. Advanced T-classification and regional lymph-node metastases had significant negative impact on survival rates.CONCLUSION: The incidence of submandibular gland carcinoma in Denmark was 0.17/100,000/year and stable during the time period. The most frequent subtype was adenoid cystic carcinoma. Half of the recurrences presented in a distant site, and multivariate analysis confirmed that advanced stage was independent negative prognostic factor for recurrence and survival.

KW - Salivary gland carcinoma

KW - Submandibular gland cancer

KW - Submandibular gland carcinoma

U2 - 10.1007/s00405-023-07940-y

DO - 10.1007/s00405-023-07940-y

M3 - Journal article

C2 - 37052687

SN - 0942-8992

SN - 1434-4726

VL - 280

SP - 3405

EP - 3413

JO - European Archives of Oto-Rhino-Laryngology

JF - European Archives of Oto-Rhino-Laryngology

IS - 7

ER -

Epidemiology, outcomes, and prognostic factors in submandibular gland carcinomas: a national DAHANCA study

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