Endothelium-dependent remote signaling in ischemia and reperfusion: alterations in the cardiometabolic continuum

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

  • Ralf Erkens, Heinrich Heine Univ Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf Hospital, Univ Hosp Dusseldorf, Dept Gynaecol & Obstet
  • ,
  • Matthias Totzeck, Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
  • ,
  • Amanda Brum, Heinrich Heine Univ Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf Hospital, Univ Hosp Dusseldorf, Dept Gynaecol & Obstet
  • ,
  • Dragos Duse, Heinrich Heine Univ Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf Hospital, Univ Hosp Dusseldorf, Dept Gynaecol & Obstet
  • ,
  • Hans Erik Bøtker
  • Tienush Rassaf, Institute for Virology, University Hospital Essen, University of Duisburg-Essen, 45147 Essen, Germany.
  • ,
  • Malte Kelm, Heinrich Heine Univ Dusseldorf, Heinrich Heine University Dusseldorf, Heinrich Heine University Dusseldorf Hospital, Univ Hosp Dusseldorf, Dept Gynaecol & Obstet

Intact endothelial function plays a fundamental role for the maintenance of cardiovascular (CV) health. The endothelium is also involved in remote signaling pathway-mediated protection against ischemia/reperfusion (I/R) injury. However, the transfer of these protective signals into clinical practice has been hampered by the complex metabolic alterations frequently observed in the cardiometabolic continuum, which affect redox balance and inflammatory pathways. Despite recent advances in determining the distinct roles of hyperglycemia, insulin resistance (InR), hyperinsulinemia, and ultimately diabetes mellitus (DM), which define the cardiometabolic continuum, our understanding of how these conditions modulate endothelial signaling remains challenging. It is widely accepted that endothelial cells (ECs) undergo functional changes within the cardiometabolic continuum. Beyond vascular tone and platelet-endothelium interaction, endothelial dysfunction may have profound negative effects on outcome during I/R. In this review, we summarize the current knowledge of the influence of hyperglycemia, InR, hyperinsulinemia, and DM on endothelial function and redox balance, their influence on remote protective signaling pathways, and their impact on potential therapeutic strategies to optimize protective heterocellular signaling.

OriginalsprogEngelsk
TidsskriftFree Radical Biology & Medicine
Vol/bind165
Sider (fra-til)265-281
Antal sider17
ISSN0891-5849
DOI
StatusUdgivet - mar. 2021

Se relationer på Aarhus Universitet Citationsformater

ID: 209931282