Emerging regulation and functions of autophagy

Patricia Boya; Fulvio Reggiori; Patrice Codogno

doi:10.1038/ncb2788

Emerging regulation and functions of autophagy

Patricia Boya, Fulvio Reggiori, Patrice Codogno

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avis › Review › Forskning › peer review

1016 Citationer (Scopus)

Abstract

Autophagy maintains cell, tissue and organism homeostasis through degradation. Complex post-translational modulation of the Atg (autophagy-related) proteins adds additional entry points for crosstalk with other cellular processes and helps define cell-type-specific regulations of autophagy. Beyond the simplistic view of a process exclusively dedicated to the turnover of cellular components, recent data have uncovered unexpected functions for autophagy and the autophagy-related genes, such as regulation of metabolism, membrane transport and modulation of host defenses--indicating the novel frontiers lying ahead.

Originalsprog	Engelsk
Tidsskrift	Nature Cell Biology
Vol/bind	15
Nummer	7
Sider (fra-til)	713-20
Antal sider	8
ISSN	1465-7392
DOI	https://doi.org/10.1038/ncb2788
Status	Udgivet - jul. 2013
Udgivet eksternt	Ja

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10.1038/ncb2788

Citationsformater

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KW - Autophagy/physiology

KW - Biological Transport

KW - Host-Pathogen Interactions

KW - Humans

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Emerging regulation and functions of autophagy

Abstract

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