Emerging interactions between diet, gastrointestinal helminth infection, and the gut microbiota in livestock

Publikation: Bidrag til tidsskrift/Konferencebidrag i tidsskrift /Bidrag til avisReviewForskningpeer review

DOI

  • Andrew R. Williams, Københavns Universitet
  • ,
  • Laura J. Myhill, Københavns Universitet
  • ,
  • Sophie Stolzenbach, Københavns Universitet
  • ,
  • Peter Nejsum
  • Helena Mejer, Københavns Universitet
  • ,
  • Dennis S. Nielsen, Københavns Universitet
  • ,
  • Stig M. Thamsborg, Københavns Universitet

Increasing evidence suggests that nutritional manipulation of the commensal gut microbiota (GM) may play a key role in maintaining animal health and production in an era of reduced antimicrobial usage. Gastrointestinal helminth infections impose a considerable burden on animal performance, and recent studies suggest that infection may substantially alter the composition and function of the GM. Here, we discuss the potential interactions between different bioactive dietary components (prebiotics, probiotics and phytonutrients) and helminth infection on the GM in livestock. A number of recent studies suggest that host diet can strongly influence the nature of the helminth-GM interaction. Nutritional manipulation of the GM may thus impact helminth infection, and conversely infection may also influence how the GM responds to dietary interventions. Moreover, a dynamic interaction exists between helminths, the GM, intestinal immune responses, and inflammation. Deciphering the mechanisms underlying the diet-GM-helminth axis will likely inform future helminth control strategies, as well as having implications for how health-promoting feed additives, such as probiotics, can play a role in sustainable animal production.

OriginalsprogEngelsk
Artikelnummer62
TidsskriftBMC Veterinary Research
Vol/bind17
ISSN1746-6148
DOI
StatusUdgivet - dec. 2021

Bibliografisk note

Funding Information:
We acknowledge all of our group members and collaborators for fruitful discussions.

Publisher Copyright:
© 2021, The Author(s).

Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.

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